{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:51Z","timestamp":1760188851314},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8251,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1983,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clonal chromosome abnormalities were observed in 30 patients with non\u2010Hodgkin's lymphoma; the type of lymphoma was characterized on the basis of the International Working Formulation. The 30 patients were classified into five groups according to the chromosome abnormality. There were 8 patients with t(14;18), 3 with t(8;14), 7 with a translocation to the long arm of chromosome 3 (a 3q+ chromosome), 5 with near\u2010tetraptoidy, and 7 with other abnormalities. Among the 8 patients with t(14;18), 5 had follicular small cleaved\u2010cell lymphoma (FSC), I had follicular mixed cell lymphoma (FM), and 2 had diffuse large\u2010cell lymphoma (DL); the diagnosis in these 2 patients was based on extranodal tissue. All 3 patients with t(8;14) had DL and B\u2010cell markers. Except for I patient, all those with a 3q+ chromosome had DL; 4 of those who were tested had B\u2010cell or pre\u2010B\u2010cell markers. Four of the 5 patients with near\u2010tetraploidy had follicular mixed\u2010cell lymphoma, and 2 of the 7 patients with other abnormalities had T\u2010cell lymphoma. Thus, patients with a t(8;14), a 14q+ chromosome, or a 3q+ chromosome all tend to have diffuse large\u2010cell lymphoma, usually of the non\u2010cleaved type. On the other hand, our data suggest that patients with FSC generally have a t(14;18) whereas those with follicular and diffuse mixed small cleaved cells and large non\u2010cleaved cells have a different pattern with modal chromosome numbers in the tetraploid range. We added 17 previously reported patients to the 30 presented here and correlated the karyotype with survival. The 6 patients with near\u2010tetraploidy had the longest median survival, 69 months, the 15 patients with t(14;18) had the next longest, 48 months. The 4 patients with (8;14) had Che shortest urvival, 12 months, and the 9 with other abnormalities had the next shortest, 17 months. Intermediate survivals of 27 and 30 months were observed in patients with a 14q+ or a 3q+ chromosome, respectively. The median survival of thaw various categories differs and our data, thus, indicate that the karyotypic pattern of the malignant cell may be a significant independent prognostic feature influencing the survival of patients with non\u2010Hodgkin's lymphoma.<\/jats:p>","DOI":"10.1002\/ijc.2910320606","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:27:03Z","timestamp":1171913223000},"page":"683-692","source":"Crossref","is-referenced-by-count":50,"title":["Prognostic implications of karyotype and morphology in patients with non\u2010Hodgkin's lymphoma"],"prefix":"10.1002","volume":"32","author":[{"given":"Yasuhiko","family":"Kaneko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daina","family":"Variakojis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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