{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:38:26Z","timestamp":1759333106507},"reference-count":65,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8251,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1983,12,15]]},"abstract":"Abstract<\/jats:title>Mouse and human (HL\u201060) MGI+<\/jats:sup>D+<\/jats:sup> myeloid leukemic cells were induced to differentiate to mature cells in diffusion chambers implanted into the peritoneal cavity of normal mice when a xenogeneic source of serum was added to the diffusion chambers. Differentiation was inhibited in immune deficient mice including congenitally athymic nude and neonatally thymectomized mice, and mice treated with cyclophosphamide, hydrocortisone, or X\u2010irradiation. There was no such inhibition of differentiation in mice with various genetic defects in their B lymphocytes, granulocytes, erythrocytes and natural killer cells. Differentiation in cyclophosphamide\u2010treated mice was restored by a single intravenous injection of normal spleen cells highly enriched for T lymphocytes. Conditions permissive for differentiation were associated with a higher number of eosinophils in the peritoneum than conditions that inhibited differentiation. Intraperitoneal injections of inflammatory peritoneal exudate cells, peritoneal granulocytes, or the inflammation inducer sodium caseinate, restored the ability of defective mice to induce differentiation. Injections into defective mice of the normal mouse macrophage and granulocyte differentiation\u2010inducing protein (MGI\u20102) restored differentiation of the mouse myeloid leukemic cells but not of the human myeloid leukemic cells. Differentiation of normal mouse bone marrow myeloid precursors to mature cells and of differentiation\u2010defective (MGI\u2010D\u2010) mouse myeloid leukemic cells to intermediate stages of differentiation were not affected by the conditions that inhibited differentiation of the MGI +<\/jats:sup>D+<\/jats:sup> myeloid leukemic cells. The results indicate: 1) that the intraperitoneal accumulation of inflammatory cells, including eosinophils, can induce differentiation of MGI +<\/jats:sup>D+<\/jats:sup> leukemic cells in the peritoneal cavity; 2) that this response requires T lymphocytes and can be regulated by xenogeneic serum in the chamber; 3) that in vivo<\/jats:italic> diffentiation of normal and MGI +<\/jats:sup>D+<\/jats:sup> myeloid leukemic cells can be regulated in different ways; and 4) that the in vivo<\/jats:italic> differentiation of the mouse MGI +<\/jats:sup>D+<\/jats:sup> leukemic cells, human MGI+<\/jats:sup>D+<\/jats:sup> leukemic cells and mouse MGI\u2212<\/jats:sup>D\u2212<\/jats:sup> leukemic cells were induced by different compounds, so that differentiation of different types of leukemic cells may be differently regulated in vivo<\/jats:italic> depending on which compounds induce differentiation.<\/jats:p>","DOI":"10.1002\/ijc.2910320620","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:27:03Z","timestamp":1171913223000},"page":"781-791","source":"Crossref","is-referenced-by-count":16,"title":["Control of in vivo<\/i> differentiation of myeloid leukemic cells. III. Regulation By T Lymphocytes And Inflammation"],"prefix":"10.1002","volume":"32","author":[{"given":"Joseph","family":"Lotem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"487","volume-title":"Mononuclear phagocytes in immunity, infection and pathology","author":"Allison A. C.","year":"1975"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040770202"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1970.tb01899.x"},{"key":"e_1_2_1_5_1","first-page":"235","article-title":"Characterization and significance of abnormal leukocyte granules in the beige mouse: a possible homologue for Chediak\u2010Higashi Aleutian trait","volume":"73","author":"Bennet J. N.","year":"1969","journal-title":"J. lab. clin. Med."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1182\/blood.V36.4.458.458","article-title":"Mechanism of eosinophilia. III. Suppression of eosinophilia by agents known to modify immune responses","volume":"36","author":"Boyer M. H.","year":"1970","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910260517"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.1.353"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910250208"},{"key":"e_1_2_1_10_1","first-page":"343","article-title":"Terminal differentiation of human promyelocytic leukemia by dimethylsulfoxide and other polar compounds","volume":"70","author":"Collins S. J.","year":"1978","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830070517"},{"key":"e_1_2_1_12_1","first-page":"234","article-title":"Defective helper T\u2010cell activity in the LPS\u2010unresponsive C3H\/HeJ mice","volume":"70","author":"D'Agostaro G.","year":"1982","journal-title":"Cell Immunoll."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910260511"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1182\/blood.V45.4.495.495","article-title":"Cultivation of leukemic human bone marrow cells in diffusion chambers implanted into normal and irradiated mice","volume":"45","author":"Fauerholdt L.","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.2.343"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio237276a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040860205"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1182\/blood.V43.2.201.201","article-title":"Granulocyte function in the Chediak\u2010Highashi syndrome of mice","volume":"43","author":"Gallin J. I.","year":"1974","journal-title":"Blood"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1975.133"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910280514"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040740303"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.58.4.1480"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830031011"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(76)90131-8"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.10.2540"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910280306"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290208"},{"key":"e_1_2_1_28_1","first-page":"522","article-title":"Studies in experimental eosinophilia. III. The induction of peritoneal eosinophilia by the passive transfer of serum antibody","volume":"87","author":"Litt M.","year":"1961","journal-title":"J. Immunol."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(76)90345-2"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910250612"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.9.3507"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5554"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040920112"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.8.3781"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910220216"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.10.5158"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910250503"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910280318"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.14.4347"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320120"},{"key":"e_1_2_1_41_1","first-page":"435","article-title":"Characterization of a differentiation stimulating factor for mouse myeloid leukemic cells","volume":"68","author":"Maeda M.","year":"1977","journal-title":"Gann"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1182\/blood.V26.4.399.399","article-title":"The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype SI\/SId","volume":"26","author":"McCulloch E. A.","year":"1965","journal-title":"Blood"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040740313"},{"key":"e_1_2_1_44_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.4049\/jimmunol.130.3.1103","article-title":"Is the delayed type of hypersensitivity observed after a low dose of antigen mediated by helper T cells?","volume":"130","author":"Milon G.","year":"1983","journal-title":"J. Immunol."},{"key":"e_1_2_1_45_1","first-page":"919","article-title":"Eosinophil response to migrating Ascaris suum larvae in normal and thymus\u2010less mice","volume":"82","author":"Nielson K.","year":"1974","journal-title":"Acta path. microbiol. scand. Sec. B."},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240115"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.67.3.1542"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/217370a0"},{"key":"e_1_2_1_49_1","first-page":"594","article-title":"Schistosomiasis in the congenitally athymic (nude)mouse. I. Thymic dependency of eosinophilia, granuloma formation and host morbidity","volume":"118","author":"Phillips S. M.","year":"1977","journal-title":"J. Immunol."},{"key":"e_1_2_1_50_1","first-page":"1363","article-title":"Lymphoid cell dependence of eosinophil response to antigen. III. Comparison of the rate of appearance of two types of memory cells in various lymphoid tissues at different times after priming","volume":"110","author":"Ponzio N. M.","year":"1973","journal-title":"J. Immunol."},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/278451a0"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-152-39405"},{"key":"e_1_2_1_53_1","first-page":"1","article-title":"Regulation of membrane changes, differentiation and malignancy in carcinogenesis","volume":"68","author":"Sachs L.","year":"1974","journal-title":"Harvey Lect."},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/274535a0"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb05826.x"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.10.6152"},{"key":"e_1_2_1_57_1","first-page":"321","article-title":"Normal developmental programmes in myeloid leukemia. Regulatory proteins in the control of growth and differentiation","volume":"1","author":"Sachs L.","year":"1982","journal-title":"Cancer Surveys"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041130423"},{"key":"e_1_2_1_59_1","first-page":"199","article-title":"Growth and differentiation of normal and leukemic human bone marrow cells cultured in diffusion chambers","volume":"5","author":"Steele A. A.","year":"1977","journal-title":"Exp. Haematol."},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/2191253a0"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041110103"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1983.tb01481.x"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.3.1374"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198007033030109"},{"key":"e_1_2_1_65_1","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.4049\/jimmunol.130.4.1596","article-title":"A requirement for helper T cells in the induction of delayed type hypersensitivity","volume":"130","author":"Wright K.","year":"1983","journal-title":"J. Immunol."},{"key":"e_1_2_1_66_1","first-page":"4804","article-title":"Production by spleen cells of factors stimulating differentiation of mouse myeloid leukemic cells that differ from the colony\u2010stimulating factor","volume":"40","author":"Yamamoto Y.","year":"1980","journal-title":"Cancer Res."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910320620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910320620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T20:49:43Z","timestamp":1697748583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910320620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,12,15]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,12,15]]}},"alternative-id":["10.1002\/ijc.2910320620"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910320620","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,12,15]]}}}