{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:43:41Z","timestamp":1771490621163,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8219,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sera obtained at enrolment in the study from patients suffering from moderate to severe dysplasia (cervical intraepithelial neoplasia grade II), carcinoma <jats:italic>in situ<\/jats:italic> (cervical intraepithelial neoplasia grade III) and invasive carcinoma, or developing any of these conditions in the course of the prospective study, and from control subjects, were examined for herpes simplex type\u20102 (HSV\u20102) antibody presence. The controls were matched with the patients by age, age at first intercourse, number of sexual partners, smoking habits and history of diathermoelectrocoagulation of the ectopic epithelium and transformation zone of cervix. Only those subjects were selected as controls who remained free of pathological colposcopical and cytological findings throughout the observation period, <jats:italic>i.e.<\/jats:italic> for at least 4 years after their serum sample was obtained. The microneutralization test (MNT) and type\u20102\u2010specific solid\u2010phase radioimmunoassay (SPIRA) were used as serological tests. No difference in the prevalence of HSV\u20102 antibody between the patients and controls was revealed by either test. Various combinations of the results from the two tests also failed to show any difference between patients and controls. Moreover, no significant differences were observed in the prevalence of HSV\u20102 antibody between patients suffering from the various pathological conditions and those diagnosed at enrolment and later in the course of the study. These results do not provide any support for the hypothesis of the involvement of HSV\u20102 in cervical neoplasia.<\/jats:p>","DOI":"10.1002\/ijc.2910330111","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:23:53Z","timestamp":1171913033000},"page":"61-66","source":"Crossref","is-referenced-by-count":85,"title":["Prospective study on the relationship between cervical neoplasia and herpes simplex type\u20102 virus. II. Herpes simplex type\u20102 antibody presence in sera taken at enrolment"],"prefix":"10.1002","volume":"33","author":[{"given":"V.","family":"Vonka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Z\u00e1vadov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kr\u010dm\u00e1\u0159","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Such\u00e1nkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"\u0158ez\u00e1cov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Brou\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Press","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Domor\u00e1zkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Svoboda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Havr\u00e1nkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jelinek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1128\/jvi.44.1.344-355.1982","article-title":"Glycoproteins of herpes simples virus type\u20102 as defined by monoclonal antibodies","volume":"44","author":"Balachandran N.","year":"1982","journal-title":"J. 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