{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T07:16:41Z","timestamp":1698045401634},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8159,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In previous studies we detected retrovirus RD114 p30\u2010related antigen in human placental syncytiotrophoblasts and antibodies in cord blood sera. We now report that a monoclonal IgG antibody specific for the p19 protein of human T\u2010cell leukemia virus (HTLV) reacts with human syncytiotrophoblastic antigen. When used in the immunoperoxidase tissue\u2010staining procedure, the monoclonal antibody reacted with the syncytiotrophoblastic cells in sections of all early placentas (&lt;15 weeks of gestation), blighted ova and benign (hydatidiform mole) or malignant placental tumors (destructive mole, choriocarcinoma). In all cases the reactivity was mainly confined to the cytoplasm of the cells with syncytiotrophoblastic morphology. Normal embryonal or adult tissues tested were negative. In immunoblotting of cultured choriocarcinoma cells, anti\u2010HTLV p19 detected a single polypeptide at mol.wt 28,000 from proteins separated by electrophoresis.<\/jats:p>","DOI":"10.1002\/ijc.2910330303","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:22:48Z","timestamp":1171912968000},"page":"293-298","source":"Crossref","is-referenced-by-count":18,"title":["Monoclonal antibody to human T\u2010cell leukemia virus P19 defines polypeptide antigen in human choriocarcinoma cells and syncytiotrophoblasts of first\u2010trimester placentas"],"prefix":"10.1002","volume":"33","author":[{"given":"Jukka","family":"Suni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale","family":"N\u00e4rv\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Wahlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pentti","family":"Lehtovirta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Vaheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6189183"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.15.4709"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6342136"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.8.2346"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6601823"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6601822"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.3.907"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/294271a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/jvi.38.3.906-915.1981","article-title":"Immunological properties of type\u2010C retrovirus isolated from culture human T\u2010lymphoma cells and comparison to other mammalian retroviruses","volume":"38","author":"Kalyanaraman V. 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