{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:12:09Z","timestamp":1790694729826,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8131,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A prospective study of the prognostic significance of the labelling index (LI) was undertaken in 1972. The LI of the primary tumor was measured consecutively on 128 patients with mammary carcinoma at the time of initial treatment, following<jats:italic>in vitro<\/jats:italic>incubation of specimens with tritiated thymidine. The follow\u2010up for all patients has now extended over 10 years. Relapse\u2010free survival and total survival are significantly higher in patients with a low LI. A multivariate analysis of the prognostic factors, carried out with Cox's model, showed that Li is the most predictive indicator with respect to survival. The size of the tumor is the second most predictive indicator, while histological grading and the number of involved lymph nodes are less predictive. These results strongly suggest that proliferative activity as assessed by LI is directly related to metastatic dissemination probability, independent of other prognostic factors.<\/jats:p>","DOI":"10.1002\/ijc.2910330404","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:57:09Z","timestamp":1171915029000},"page":"441-445","source":"Crossref","is-referenced-by-count":188,"title":["The long\u2010term prognostic significance of the thymidine labelling index in breast cancer"],"prefix":"10.1002","volume":"33","author":[{"given":"M.","family":"Tubiana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Pejovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Chavaudra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Contesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. P.","family":"Malaise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1957.43"},{"key":"e_1_2_1_3_1","first-page":"145","article-title":"Labelling index of human squamous cell carcinomas. Comparison of in vivo and in vitro labelling methods","volume":"12","author":"Chavaudra N.","year":"1979","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_4_1","first-page":"525","article-title":"Les facteurs anatomo\u2010pathologiques du prognostic des cancers du sein","volume":"64","author":"Contesso G.","year":"1977","journal-title":"Bull. Cancer (Paris)"},{"key":"e_1_2_1_5_1","first-page":"1","article-title":"Labelling index as a prognostic marker in non\u2010Hodskin's lymphomas","volume":"66","author":"Costa A.","year":"1981","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and like tables (with discussion)","volume":"34","author":"Cox D. R.","year":"1972","journal-title":"J. statist. Soc., B."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810815)48:4<974::AID-CNCR2820480420>3.0.CO;2-#"},{"key":"e_1_2_1_8_1","first-page":"479","article-title":"L'index de marquage dans les cancers du sein et des voies a\u00e9rodigestives sup\u00e9rieures","volume":"66","author":"Gioanni J.","year":"1979","journal-title":"Bull. Cancer (Paris)"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197704)39:4<1603::AID-CNCR2820390435>3.0.CO;2-8"},{"key":"e_1_2_1_10_1","unstructured":"Koscielny S. Tubiana M. L\u00e9 M. Valleron A. J. Mouriesse H. Contesso G. andSarrazin D. Breast cancer: relationship between the size of the primary tumour and the probability of metastatic dissemination. (Brit. J. Cancer). (In press)."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197306)31:6<1468::AID-CNCR2820310623>3.0.CO;2-U"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830515)51:10<1879::AID-CNCR2820511021>3.0.CO;2-9"},{"key":"e_1_2_1_13_1","first-page":"4042","article-title":"Advanced stage and early relapse of breast carcinomas associated with high thymidine labelling indices","volume":"39","author":"Meyer J. S.","year":"1979","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","first-page":"242","article-title":"Radiotherapeutic studies on breast cancer at Villejuif","volume":"34","author":"Sarrazin D.","year":"1982","journal-title":"Cancer Bull. (Houston)"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1980.139"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(82)90607-1"},{"key":"e_1_2_1_17_1","first-page":"341","article-title":"Vitesse de croissance et histoire naturelle du cancer du sein","volume":"62","author":"Tubiana M.","year":"1975","journal-title":"Bull. Cancer (Paris)"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810301)47:5<937::AID-CNCR2820470520>3.0.CO;2-6"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910330404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910330404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T22:03:39Z","timestamp":1736805819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910330404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4,15]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,4,15]]}},"alternative-id":["10.1002\/ijc.2910330404"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910330404","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4,15]]}}}