{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:29:10Z","timestamp":1759332550368},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8067,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The number and distribution of reactive T cells within 100 malignant B\u2010cell lymphomas were evaluated <jats:italic>in situ<\/jats:italic> by immunomorphometry using stereological methods. Findings were related to histological and clinical parameters. A mean of 2 \u00d7 10<jats:sup>4<\/jats:sup> reactive T cells\/\u03bcI tumour tissue was found. This corresponds to 40% of the T\u2010cell content of normal lymphatic tissues. The distribution of reactive T cells within the tumours was diffuse except for centroblastic\/centrocytic lymphomas. When evaluating the different histological entities a correlation between number of helper T cells, T helper:T suppressor (T<jats:sub>H<\/jats:sub>:T<jats:sub>S<\/jats:sub>) ratio and histological subgroups emerged, particularly in non\u2010Hodgkinlymphomas of low\u2010grade malignancy. The highest ratio was found in prognostically favourable subgroups, CLL(2.7 \u00b1 0.3) and tumour areas of centroblastic\/centrocytic lymphomas (2.9 \u00b1 0.4). In contrast, a significantly lower ratio was found in centrocytic lymphomas (1.4 \u00b1 0.3) corresponding well to the worst prognosis of this subgroup. The relationship between the number of helper T cells in tumour tissues, T<jats:sub>H<\/jats:sub>:T<jats:sub>S<\/jats:sub> ratio and prognosis was confirmed and extended by the evaluation of clinical data. It could be shown that, independently of histological criteria, a close correlation exists between the number of T cells, particularly T helper cells within the tumour, T<jats:sub>H<\/jats:sub>:T<jats:sub>S<\/jats:sub> ratio and clinical course. Patients with a favourable course had 1.4 \u00d7 10<jats:sup>4<\/jats:sup> T helper cells\/\u03bcI tumour tissue compared to only 0.8 \u00d7 10<jats:sup>4<\/jats:sup> for patients with an unfavourable clinical course (p&lt;0.01); the T<jats:sub>H<\/jats:sub>:T<jats:sub>S<\/jats:sub> ratio was 2.8 for the favourable and 1.8 for the unfavourable group, respectively (p&lt;0.04). In contrast, neither treatment nor tumour stage had a clear\u2010cut influence on the extent of T\u2010cell infiltration.<\/jats:p>","DOI":"10.1002\/ijc.2910330607","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:45:18Z","timestamp":1171914318000},"page":"751-757","source":"Crossref","is-referenced-by-count":18,"title":["Imbalance of helper and suppressor T lymphocytes in malignant non\u2010hodgkin lymphomas: An <i>In situ<\/i> morphometric analysis"],"prefix":"10.1002","volume":"33","author":[{"given":"C.","family":"Gattringer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Radaszkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Pfaller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Braunsteiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"449","article-title":"The use of monoclonal anti\u2010T\u2010cell antibodies to study T\u2010cell imbalances in human diseases","volume":"45","author":"Bach M. 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