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Serum IgA, IgG, IgG subclasses, IgE, <jats:italic>Schistosoma<\/jats:italic> and <jats:italic>Ascaris<\/jats:italic>\u2010specific IgE (RAST) and the acute\u2010phase protein CRP were measured in all, or sub\u2010sets, of the main patient group. The well\u2010established increase in IgE and IgG levels, and the more recently reported increase in the levels of IgG3 and IgG4 subclasses in patients with schistosomiasis, were also found in bilharzial bladder cancer, indicating that humoral immunity persists in cancer\u2010bearing patients. However, the plasma protein profile in bilharzial bladder cancer is further modified by significant increases in the levels of IgA, IgG, IgGI, IgG2 and CRP when compared to levels in patients with <jats:italic>Bilharzia<\/jats:italic> in the absence of neoplastic change. Patients with cancers not associated with parasitic infestation also had significant increases in their serum levels of IgGI, IgG2, IgG, IgE and CRP when compared to healthy Egyptian controls, but 41% of these non\u2010bladder cancer patients showed IgE responses to previous parasitic infestations suggesting that any immunological response to cancer would be on the background of a variable non\u2010specific increase of IgE.<\/jats:p>","DOI":"10.1002\/ijc.2910330610","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:45:18Z","timestamp":1171914318000},"page":"771-775","source":"Crossref","is-referenced-by-count":2,"title":["Immunoglobulin A, G and E levels in egyptians with cancer: Influence of schistosomiasis"],"prefix":"10.1002","volume":"33","author":[{"given":"N. B.","family":"Pidcock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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