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(1) Tumour cells which were positive for Epstein\u2010Barr nuclear antigen, HLA\u2010ABC and keratin determinants. In most samples, the tumour cells also expressed variable amounts of HLA\u2010DR antigens. The presence of HLA\u2010DR antigens has not been previously reported in NPC and may be a contributory factor in effecting the transfer of Epstein\u2010Barr virus to the epithelial cells. (2) Infiltrating lymphocytes which were mainly composed of T inducer (T4<jats:sup>+<\/jats:sup>) and T suppressor\/cytotoxic (T8<jats:sup>+<\/jats:sup>) cells although one sample contained predominantly immature T cells expressing the HTA\u20101<jats:sup>+<\/jats:sup> cortical thymocyte phenotype. Few B cells or natural killer cells were demonstrated. (3) Large HTA\u20101<jats:sup>+<\/jats:sup> dendritic cells which were invariably present within the tumour masses. These were morphologically and phenotypically similar to antigen presenting Langerhans cells which are usually located in the skin but also found in other epithelial sites. These cells may be a residual population from the normal nasopharynx or represent part of a specific immunological response to the presence of Epstein\u2010Barr virus in the epithelial cells.<\/jats:p>","DOI":"10.1002\/ijc.2910330616","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:45:18Z","timestamp":1171914318000},"page":"813-819","source":"Crossref","is-referenced-by-count":36,"title":["Expression of HLA\u2010DR antigens in nasopharyngeal carcinoma: An immunohistological analysis of the tumour cells and infiltrating lymphocytes"],"prefix":"10.1002","volume":"33","author":[{"given":"J. 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