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Using proteins and synthetic selective substrates, we observed the presence of collagen\u2010peptidases, plasminogen activator, cathepsin\u2010B and cathepsin\u2010D\u2010like enzymes, and sialyltransferase. No active or trypsin\u2010activatable type\u2010IV collagenase activity was detected. Although individual variations between tumors were large, proteinase and sialyltransferase contents were significantly elevated in malignant breast tissues. Enzyme activities were found to be related to the epithelial volume of the tumor. No significant correlation was found between the proteinase or sialyltransferase activities and the degree of differentiation of the tumor cells, or the degree to which tumors had metastasized to regional lymph nodes. Since large variations of enzyme levels apparently reflect the heterogeneity of epithelial cell densities in tumor samples, proteolytic or sialyltransferase activities cannot therefore be used as a measure of quantitative evaluation of invasive properties in breast cancer.<\/jats:p>","DOI":"10.1002\/ijc.2910330617","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:45:18Z","timestamp":1171914318000},"page":"821-824","source":"Crossref","is-referenced-by-count":17,"title":["Proteinases and sialyltransferase in human breast tumors"],"prefix":"10.1002","volume":"33","author":[{"given":"Joseph","family":"Abecassis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gine","family":"Collard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Eber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Pusel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean P.","family":"Fricker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00c9Rard","family":"Methlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"283","article-title":"Die Freisetzung von Proteinasen aus neutrophilen Leukozyten und Makrophagen","volume":"35","author":"Baggiolini M.","year":"1979","journal-title":"Bull. 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