{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:41:18Z","timestamp":1790937678125,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8006,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Epstein\u2010Barr virus (EBV) has been consistently found to be associated with Hodgkin's disease (HD) in two ways: cases generally have elevated titer distributions of antibodies against the viral capsid antigen, and the occurrence of HD among persons with a history of EBV infectious mononucleosis is two or three times higher than expected. We evaluated this association by measuring the prevalence and level of antibodies against EBV and related viruses among 304 cases of HD interviewed in a population\u2010based study in comparison to 285 of their siblings. The most significant finding was that antibody titers to the viral capsid antigen of EBV were elevated (\u00b1 1:320) in 39% of the cases and in only 14% of the sibling\u2010controls; the relative risk adjusted for age and sex was 4.1. The geometric mean titer was three\u2010fold higher among cases (175.6vs. 58.1) Subjects who reported a history of IM had a higher distribution of titers than those who did not. Cases also had elevated titers against the early antigen of EBV \u2010 the D Component being most prominent. A significantly higher proportion of cases has elevated titers against CMV, relative risk = 3.4, but the prevalence of CMV antibody was relatively low and not consistently higher among cases. The findings support the hypothesis that EBV may play a role in the pathogenesis of HD among persons with elevated titers. The findings neither confirm nor deny a possible role of CMV.<\/jats:p>","DOI":"10.1002\/ijc.2910340203","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:44:38Z","timestamp":1171914278000},"page":"149-157","source":"Crossref","is-referenced-by-count":87,"title":["A population\u2010based case\u2010control study of EBV and other viral antibodies among persons with Hodgkin's disease and their siblings"],"prefix":"10.1002","volume":"34","author":[{"given":"Alfred S.","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Gutensohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1128\/iai.14.4.970-975.1976","article-title":"Viral infection in renal transplant recipients","volume":"14","author":"Armstrong J. A.","year":"1976","journal-title":"Inf. Immunol."},{"key":"e_1_2_1_3_1","first-page":"304","article-title":"A nationwide survey of US military recruits, 1962. III. Measles and mumps antibodies","volume":"80","author":"Black F. L.","year":"1964","journal-title":"Amer. J. Hygiene"},{"key":"e_1_2_1_4_1","first-page":"248","volume-title":"The analysis of case\u2010control studies","author":"Breslow N. E.","year":"1980"},{"key":"e_1_2_1_5_1","unstructured":"Casey H. L. Standardized diagnostic complement fixation method and adaptation to micro test. Public Health Monograph No. 74 United States Department of Health Education and Welfare Washington D.C. (1968)."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910090214"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/274756a0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jnci\/61.1.19","article-title":"Epstein\u2010Barr virus infections in Brazil. II. Hodgkin's disease","volume":"61","author":"Evans A. S.","year":"1978","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92351-5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/oxfordjournals.aje.a113033","article-title":"A case\u2010control study of Hodgkin's disease in Brazil. II. Seroepidemiologic studies in cases and family members","volume":"112","author":"Evans A. S.","year":"1980","journal-title":"Amer. J. Epidem."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197008)26:2<327::AID-CNCR2820260213>3.0.CO;2-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197511)36:5<1640::AID-CNCR2820360517>3.0.CO;2-V"},{"key":"e_1_2_1_13_1","first-page":"689","article-title":"Social class and age at diagnosis of Hodgkin's disease. New epidemiologic evidence of the \u201ctow\u2010disease\u201d hypothesis","volume":"66","author":"Gutensohn N.","year":"1982","journal-title":"Cancer Treat. Rep."},{"key":"e_1_2_1_14_1","first-page":"92","article-title":"Epidemiology of Hodgkin's disease","volume":"7","author":"Gutensohn N.","year":"1980","journal-title":"Sem. Oncol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101153040302"},{"key":"e_1_2_1_16_1","first-page":"1443","article-title":"Case\u2010control study of Hodgkin's disease. II. Herpesvirus group antibody titers and HL\u2010A type","volume":"51","author":"Henderson B. E.","year":"1973","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_17_1","first-page":"79","article-title":"Epstein\u2010Barr virus\u2010related serology in Hodgkin's disease","volume":"36","author":"Henle W.","year":"1973","journal-title":"Nat. Cancer Inst. Monogr."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80006-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910080212"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190108"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149972"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:4<1080::AID-CNCR2820340418>3.0.CO;2-N"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910060316"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910220503"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197408)34:2<262::AID-CNCR2820340207>3.0.CO;2-H"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197102)27:2<416::AID-CNCR2820270227>3.0.CO;2-W"},{"key":"e_1_2_1_27_1","first-page":"826","article-title":"Measurement of rubella antibody to hemagglutination inhibition. II. Characteristics of an improved HAI test employing a new method for the removal of non\u2010immunoglobulin HA inhibitors from serum","volume":"104","author":"Liebhaber H.","year":"1970","journal-title":"J. Immunol."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.2307\/2285664"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112220"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2065::AID-CNCR2820440617>3.0.CO;2-G"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60886-6"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910160216"},{"key":"e_1_2_1_33_1","first-page":"701","article-title":"Epstein\u2010Barr virus antibody in childhood Hodgkin's disease","volume":"136","author":"Shope T. C.","year":"1982","journal-title":"Amer. J. Dis. Child."},{"key":"e_1_2_1_34_1","first-page":"338","article-title":"Discordance of the Epstein\u2010Barr virus (EBV) specific humoral and cellular immunity in patients with malignant lymphomas: elevated antibody titers and lowered in vitro lymphocyte reactivity","volume":"34","author":"ten Napel H. H.","year":"1978","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_35_1","first-page":"145","article-title":"Cytomegalovirus\u2010specific immune response and the cellular immune status of malignant lymphoma","volume":"4","author":"ten Napel H. H.","year":"1980","journal-title":"J. clin. Lab. Immunol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910340203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910340203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T20:05:31Z","timestamp":1697745931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910340203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8,15]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,8,15]]}},"alternative-id":["10.1002\/ijc.2910340203"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910340203","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,8,15]]}}}