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Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4\u2010T\u2010CLL In four patients cytogenetic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA\u2010stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4\u2010T\u2010CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.<\/jats:p>","DOI":"10.1002\/ijc.2910340206","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:44:38Z","timestamp":1171914278000},"page":"171-176","source":"Crossref","is-referenced-by-count":20,"title":["Chromosome studies in patients with T\u2010CLL chronic lymphocytic leukemia and expansions of granular lymphocytes"],"prefix":"10.1002","volume":"34","author":[{"given":"B.","family":"Dallapiccola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Alimena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Chessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gastaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"De Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Semenzato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Quinti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pandolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1182\/blood.V58.4.818.818","article-title":"Chronic T\u2010cell lymphocytosis with neutropenia: report of a case studied with monoclonal antibodies","volume":"58","author":"Alsenberg A. 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