{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T20:40:46Z","timestamp":1697748046388},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":8006,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experiments were performed to examine the kinetics of delayed\u2010type hypersensitivity (DTH) to mitomycin\u2010C\u2010treated syngeneic murine fibrosarcomas inoculated into the footpads of mice. Evidence is presented to show that a \u201cstrongly\u201d antigenic tumour, designated H7, elicits consecutive waves of footpad swelling in both primary and secondary responses. Periods of anti\u2010tumour resistance coincided with the expression of each successive wave of footpad swelling in normal and immune mice. The downregulation of the response, between the successive peaks of footpad swelling, was accompanied by active tumour growth. In contrast, the non\u2010cross\u2010reacting \u201cweakly\u201d antigenic tumour, designated HI, induced footpad swelling which was expressed only once after either primary or secondary sensitization. Unlike that induced by the \u201cstrongly\u201d antigenic H7 tumour, the anti\u2010tumour immunity to the HI tumour was not sustained beyond its initial specific phase. Consequently, HI tumour cells which survived the initial phase of anti\u2010tumour immunity appeared to encounter no further resistance. Thus the distinctive feature of the \u201cweakly\u201d antigenic HI tumour was its inability to sustain consecutive waves of tumour resistance as exhibited by the \u201cstrongly\u201d antigenic H7 tumour. It is proposed that \u201cweakly\u201d and \u201cstrongly\u201d antigenic tumours are distinguished by their different abilities to down\u2010regulate the anti\u2010tumour immune response. The \u201cweakly\u201d antigenic tumour induces specific immunity which is rapidly down\u2010regulated while that induced by the \u201cstrongly\u201d antigenic tumour is sustained by successive waves of antitumour activity of diminshing intensity. Suppression of some but not all waves of footpad swelling occurred in mice with growing H7 tumours.<\/jats:p>","DOI":"10.1002\/ijc.2910340218","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:44:38Z","timestamp":1171914278000},"page":"255-261","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of anti\u2010tumour immunity induced by syngeneic mitomycin C\u2010treated murine tumour cells"],"prefix":"10.1002","volume":"34","author":[{"given":"R.","family":"Kearney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Harrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1974.0078"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5974.18"},{"key":"e_1_2_1_4_1","first-page":"779","article-title":"Immunologic evaluation of patients with cancer by delayed hypersensivity reactions","volume":"141","author":"Burdick J. 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