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Adults infected with <jats:italic>Trypanosoma cruzi<\/jats:italic> had the highest HTLV\u2010I antibody prevalence of 15%. Areas of high antibody prevalence were correlated most strongly with the presence of arthropodborne diseases and to a lesser extent with socio\u2010economic factors. Genetic factors were not correlated with antibody prevalence. Antibodies were seen in children as young as 3 years of age in the most endemic areas. Antibody titers increased with age, suggesting continuous exposure to the virus. The data provide clues for elucidation of the geographic variation in HTLV\u2010I antibody prevalence seen Venezuela and other HTLV\u2010I endemic areas. In addition, they further confirm the Caribbean region as being endemic for HTLV\u2010I and extend this region to inland areas of South America.<\/jats:p>","DOI":"10.1002\/ijc.2910340412","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:40:47Z","timestamp":1171914047000},"page":"501-506","source":"Crossref","is-referenced-by-count":57,"title":["Natural antibodies to human T\u2010cell leukemia\/lymphoma virus in healthy venezuelan populations"],"prefix":"10.1002","volume":"34","author":[{"given":"Fernando","family":"Merino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Robert\u2010Guroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Biondo\u2010Bracho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Blattner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","unstructured":"Biggar R. 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