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Proviral sequences were detected by Southern blot analysis in three T\u2010cell lines established from this patient's peripheral blood lymphocytes (PBL) and lymph\u2010node cells. We molecularly cloned and analyzed proviruses from two of these cell lines, one established by direct culture of PBL and one established by co\u2010cultivation of PBL with cord\u2010blood T cells. These two HTLV clones contained full\u2010length proviruses which were identical to each other in 44 out of 44 restriction enzyme sites. They were closely related to, but distinct from, the prototype HTLV\u2010I, having divergence in their envelope and 5\u2032 pX regions and therefore represented a new variant of HTLV\u2010I. We designated it as HTLV\u2010Ib. Despite the genomic differences, however, HTLV\u2010Ib retained its tropism for OKT4+ lymphocytes as well as its ability to initiate and maintain transformation of these cells. The finding of a variant of HTLV\u2010I in this African ATL patient, along with the results of recent seroepidemiological studies, extends to the African continent the prevalence of HTLV\u2010I associated malignancy previously identified in the Caribbean and Japan.<\/jats:p>","DOI":"10.1002\/ijc.2910340505","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:40:19Z","timestamp":1171914019000},"page":"613-618","source":"Crossref","is-referenced-by-count":54,"title":["Molecular cloning and analysis of a new variant of human T\u2010cell leukemia virus (HTLV\u2010Ib) from an African patient with adult T\u2010cell leukemia\u2010lymphoma"],"prefix":"10.1002","volume":"34","author":[{"given":"Beatrice H.","family":"Hahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikulas","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita Lo","family":"Monico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flossie","family":"Wong\u2010Staal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6189183"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.16.4848"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/305060a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402233100804"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6328663"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90306-9"},{"key":"e_1_2_1_8_1","first-page":"113","volume-title":"Cancer surveys","author":"Gallo R. 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