{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:40:21Z","timestamp":1697866821671},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7898,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1984,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a chromosome translocation t(2;13) (p11\u201012;p11) involving the kappa (<jats:italic>x<\/jats:italic>) light chain gene region (2p11\u201012), and a subsequent translocation t(11;22) (q23;11) involving the lambda (\u03bb) light chain gene region (22qll) within the same clone, in a patient with B\u2010cell prolym\u2010phocytic leukaemia (B\u2010PLL), of whose peripheral mono\u2010nuclear cells 82% expressed (<jats:italic>x<\/jats:italic>) chains and 8% expressed (\u03bb) chains. Electron microscope (EM) studies using the immunogold method showed that both <jats:italic>x<\/jats:italic>\u2212 and \u03bb\u2010producing cells were prolymphocytes. Immunoglobulin (Ig) gene analysis by Southern blotting demonstrated rearrangement of both Ig heavy (H) chain genes and one <jats:italic>x<\/jats:italic> gene. Although a \u03bb gene rearrangement corresponding to the minor \u03bb\u2010positive population was not detected, a small monoclonal (M) band of IgM\u2010\u03bb was present in the serum. The chromosome translocations and the pattern of light chain expression, particularly the \u03bb\u2010producing cells, are discussed in the light of the restricted light chain expression observed in Burkitt's lymphomas with variant translocations involving the light chain genes.<\/jats:p>","DOI":"10.1002\/ijc.2910340606","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:40:09Z","timestamp":1171914009000},"page":"769-773","source":"Crossref","is-referenced-by-count":2,"title":["Neoplastic <i>x<\/i> and \u03bb cells in a B\u2010PLL with chromosome translocations of both light chain gene regions"],"prefix":"10.1002","volume":"34","author":[{"given":"V.","family":"Brito\u2010Babapulle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Foroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Parreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Brozovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90071-1"},{"key":"e_1_2_1_3_1","first-page":"343","article-title":"Prolymphocytic leukaemia","volume":"24","author":"Catovsky D.","year":"1982","journal-title":"Nouv. Rev. fran\u00e7. H\u00e9mat."},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1182\/blood.V58.2.406.406","article-title":"Heterogeneity of B\u2010cell leukaemias demonstrated by monoclonal antibody FMC7","volume":"58","author":"Catovsky D.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_5_1","first-page":"411","article-title":"Mouse RBC rosettes in chronic lymphocytic leukaemia; different expression in blood and tissues","volume":"39","author":"Cherchi M.","year":"1980","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/294173a0"},{"key":"e_1_2_1_7_1","first-page":"63","article-title":"DNA rearrangements of immunoglobulin genes correlate with phenotypic markers in B\u2010cell malignancies","volume":"2","author":"Foroni L.","year":"1984","journal-title":"Mol. Biol. 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Oncol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06769.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90002-4"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801764"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90449-X"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.4.975"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6356357"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/298474a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.16.4957"},{"key":"e_1_2_1_17_1","first-page":"349","volume-title":"Mechanism of B\u2010cell neoplasia","author":"Perry R.","year":"1983"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90084-5"},{"key":"e_1_2_1_19_1","unstructured":"Pittman S. Cytogenetic studies in human B\u2010cell malignancies London University PhD thesis 1984."},{"key":"e_1_2_1_20_1","first-page":"257","volume-title":"Mechanisms of B\u2010cell neoplasia","author":"Preud'homme J. 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