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The sera were tested for HSV\u20102 antibodies and the biopsies were tested for HPV or HSV DNA sequences by Southern blot hybridization. HSV\u20102 sequences were detected in 2\/13 (15%) invasive neoplasms and in 1\/12 (7%) benign lesions. Under non\u2010stringent conditions of hybridization, reactions with HPV DNA were detected in biopsies of 2\/17 (12%) inflammatory lesions, 6\/12 (50%) intraepithelial neoplasms and 13\/20 (65%) invasive neoplasms. All but one of the positive biopsies of invasive cancer, but only 4\/11 biopsies of non\u2010invasive lesions, contained HPV\u201016 DNA as determined by stringent hybridization conditions. Women with cervical cancer possessed the risk factors associated with the disease. Cigarette smoking and the presence of HPV\u201016 DNA were the most prominent risk factors. No evidence of an interaction between HSV\u20102 and HPV\u201016 was found among the cases of invasive cervical cancer.<\/jats:p>","DOI":"10.1002\/ijc.2910350109","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:09:34Z","timestamp":1171915774000},"page":"51-57","source":"Crossref","is-referenced-by-count":57,"title":["Herpes simplex virus type 2 and human papillomavirus type 16 in cervicitis, dysplasia and invasive cervical carcinoma"],"prefix":"10.1002","volume":"35","author":[{"given":"S. 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