{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:54:05Z","timestamp":1763765645482},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7853,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1985,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A total of 56 cases of malignant lymphoma presumed to be of peripheral T\u2010cell origin were investigated with regard to histological and immunohistochemical features. The goal of the study was to determine whether virus\u2010associated T\u2010cell lymphomas can be morphologically or immunohistochemically distinguished from presumably virus\u2010negative T\u2010cell lymphomas. The cases came from endemic and nonendemic regions of Japan, the United Kingdom (including 4 Caribbean cases) and the Federal Republic of Germany. Sera of all Japanese and Caribbean patients and 8 German patients were tested for antibodies to adult T\u2010cell leukaemia virus\u2010associated antigen HTLV\u2010A. In all cases sections were examined blind by 5 welltrained histopathologists. In most cases cryostat sections could be prepared from fresh tissue specimens and stained with a large panel of monoclonal antibodies.<\/jats:p><jats:p>All HTLV\u2010A\u2010positive cases were morphologically classifiable as the pleomorphic type of T\u2010cell lymphoma. Approximately 70% of the tested cases of pleomorphic T\u2010cell lymphoma, however, showed a positive serum reaction for HTLV\u2010A. All other types of peripheral T\u2010cell lymphoma (T\u2010immunoblastic lymphoma, chronic lymphocytic leukaemia of T type, T\u2010zone lymphoma, \u201cAILD type\u201d and lymphoepithelioid cell lymphoma) were HTLV\u2010A\u2010negative and mostly observed in European patients. Thus virus\u2010associated T\u2010cell lymphomas appear to be invariably of the pleomorphic type; but pleomorphism is not specific to HTLV\u2010A\u2010positive cases. This was also evident from the results of an experiment in which 2 Japanese histopathologists attempted to recognize HTLV\u2010A positivity in a blind study of pleomorphic T\u2010cell lymphomas. A maximum of about 80% of cases were correctly identified, with about 10% false\u2010positive diagnoses (in HTLV\u2010A\u2010negative or presumably negative cases) and 10% false\u2010negative diagnoses.<\/jats:p><jats:p>The immunohistochemical analysis revealed not only many common features but also 2 distinct differences between HTLV\u2010A\u2010positive and \u2010negative T\u2010cell lymphomas. All but one of the HTLV\u2010A\u2010positive cases showed reactivity with anti\u2010Tac and all cases in the virus\u2010positive group were negative for T\u00dc14. All other cases were Tac\u2010negative and approximately 65% of these cases exhibited reactivity with T\u00dc14. Preliminary cytogenetic observations suggest that there are also differences in specific chromosome aberrations.<\/jats:p>","DOI":"10.1002\/ijc.2910350111","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:09:34Z","timestamp":1171915774000},"page":"65-72","source":"Crossref","is-referenced-by-count":45,"title":["HTLV\u2010positive and \u2010negative T\u2010cell lymphomas. Morphological and immunohistochemical differences between european and HTLV\u2010positive japanese T\u2010cell lymphomas"],"prefix":"10.1002","volume":"35","author":[{"given":"Karl","family":"Lennet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taizan","family":"Suchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred G.","family":"Stansfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred C.","family":"Feller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin\u2010Leo","family":"Hansmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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Cytogenet. in Press (1984).","DOI":"10.1016\/0165-4608(84)90077-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00405068"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(81)90001-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1981.tb00445.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01008087"},{"key":"e_1_2_1_11_1","first-page":"211","volume-title":"Adult T\u2010Cell leukemia and related diseases","author":"Hinuma Y."},{"key":"e_1_2_1_11_2","volume-title":"Adult T\u2010Cell leukemia and related diseases","year":"1982"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320311"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.5.1653"},{"key":"e_1_2_1_15_1","first-page":"37","volume-title":"Adult T\u2010Cell leukemia and related diseases","author":"Kikuchi M."},{"key":"e_1_2_1_15_2","volume-title":"Adult T\u2010Cell leukemia and related diseases","year":"1982"},{"key":"e_1_2_1_16_1","first-page":"407","article-title":"T\u2010Cell malignancies in adults: histopathological studies of lymph nodes in 110 patients","volume":"9","author":"Kikuchi M.","year":"1979","journal-title":"Jap. 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