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All B\u2010cell lines studied were found to be constitutive producers of a growth activity which assisted the S\u2010phase entry of normal activated B\u2010cells and provided growth support for lymphoblastoid cells transformed by Epstein\u2010Barr virus. Furthermore, all lines responded by enhanced proliferation to supernatants from a BCGF\u2010producing T\u2010cell hybridoma. Not all lines, however, displayed autostimulation to their own supernatants and no tumor B\u2010cell line appeared totally dependent on soluble factors for its growth. Non\u2010tumorigenic B\u2010cell lines, by contrast, revealed a strict dependency on homologous growith factor for their continued proliferation in suspension culture. The findings support a progression model of lymphomagenesis based upon the utilization, production and, ultimately, emancipation from growth\u2010promoting soluble factors.<\/jats:p>","DOI":"10.1002\/ijc.2910350218","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:17:37Z","timestamp":1171916257000},"page":"251-256","source":"Crossref","is-referenced-by-count":42,"title":["Capacity of B\u2010lymphocytic lines of diverse tumor origin to produce and respond to B\u2010cell growth factors: A progression model for B\u2010cell lymphomagenesis"],"prefix":"10.1002","volume":"35","author":[{"given":"John","family":"Gordon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"\u00c5man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Ros\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingemar","family":"Ernberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbro","family":"Ehlin\u2010Henriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/310655a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90071-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(81)90039-X"},{"key":"e_1_2_1_5_1","first-page":"4562","article-title":"Self\u2010Stimulat growth factor production by B\u2010Cell lines derived from Burk lymphomas and other lines transformed in vitro by Epstein virus","volume":"43","author":"Blazar B. 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