{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:53:16Z","timestamp":1774677196870,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7794,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1985,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A large sample of carriers of human T\u2010lymphotropic retrovirus type 1 (HTLV\u2010I) in Niigata Prefecture was examined for the detection of natural antibodies to HTLV\u2010I\u2010related antigens in sera using both indirect immunofluorescence microscopy (IFM) and enzyme linked immunosorbent assay (ELISA). The present findings are based on multiple surveys, using each assay technique at least twice. Although Niigata Prefecture has been considered a non\u2010endemic region for HTLV\u2010I, Sado Island has been proven by this study to be a relatively endemic pocket within this non\u2010endemic area. Seropositivity was highest in residents of Sado Island; 97\/1, 117 (8.7%) by IFM and 33\/1, 061 (3.1 %) by ELISA; followed by Niigata City, 18\/650 (2.8%) by IFM and 16\/638 (2.5%) by ELISA; and lowest in the remaining areas, 57\/2, 631 (2.2%) by IFM and 20\/2, 551 (0.8%) by ELISA. Seropositivity was demonstrated in 172\/4, 398 (3.9%) by IFM and 69\/4, 250 (1.6%) by ELISA in Niigata Prefecture taken as a whole. In general, the incidence of seropositive residents increased gradually with age. The sex difference was not significant. The serum samples tested were categorized into 4 groups; (1) IFM and ELISA both positive, (2) IFM positive but ELISA negative, (3) IFM negative but ELISA positive, and (4) IFM and ELISA both negative. By absorption tests, IFM and ELISA seemed to recognize different specific antibodies in sera; IFM recognized antibodies to HTLV\u2010I\u2010related cellular antigens in addition to HTLV\u2010I\u2010viral antigens, but ELISA recognized antibodies to HTLV\u2010I viral antigens alone. Thus, IFM detected a broader spectrum of antigens, resulting in recognition of more positive sera than those detected by ELISA.<\/jats:p>","DOI":"10.1002\/ijc.2910350304","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:15:44Z","timestamp":1171916144000},"page":"301-306","source":"Crossref","is-referenced-by-count":10,"title":["Seroepidemilogy of human T\u2010lymphotropic retrovirus type I (HTLV\u2010I) in residents of niigata prefecture, Japan. Comparative studies by indirect immunofluorescence microscopy and enzyme\u2010linked immunosorbent assay"],"prefix":"10.1002","volume":"35","author":[{"given":"Tadao","family":"Aoki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Miyakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Koide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Sugisaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Mizukoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazue","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirondo","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuya","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"Robert\u2010Guroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Modern trends in human leukemia","author":"Aoki T.","year":"1984"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90056-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood.V62.2.401.401","article-title":"The human T\u2010Cell leukemia\/lymphoma virus\u2010Associated with American adult T\u2010Cell leukemia\/lymphoma","volume":"62","author":"Blayney D. W.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92200-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.18.5680"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.15.4780"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290606"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.5.1653"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/jvi.38.3.906-915.1981","article-title":"Immunological properties of a type\u2010C retrovirus isolated from cultured human T\u2010Lymphoma cells and comparison to other mammalian retroviruses","volume":"38","author":"Kalayanaraman V. S.","year":"1981","journal-title":"J. Virol."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330602"},{"key":"e_1_2_1_14_1","volume-title":"Manipulation of host defence mechanisms","author":"Miyakoshi H.","year":"1984"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_1_16_1","first-page":"339","article-title":"Asymptomatic type\u2010C virus carriers in the family of an adult T\u2010Cell leukemia patient","volume":"73","author":"Miyoshi I.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.3.1887"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.1.248"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6760397"},{"key":"e_1_2_1_21_1","unstructured":"SADO INVESTIGATION COMMITTEE OF KYUGAKU ASSOCIATION Sado\u2013nature culture and society. Heibonsha Tokyo(1964). (In Japanese.)"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.8.2370"},{"key":"e_1_2_1_23_1","first-page":"371","article-title":"Application of the indirect ELISA microtest to the detection and surveillance of human T\u2010Cell leukemia\u2010Lymphoma virus (HTLV)","volume":"49","author":"Saxinger C.","year":"1983","journal-title":"Lab. Invest."},{"key":"e_1_2_1_24_1","first-page":"657","article-title":"Adult T\u2010Cell leukemia observed at Niigata University Hospital","volume":"13","author":"Shibata A.","year":"1983","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_25_1","first-page":"886","article-title":"Antibodies against three purified proteins of the human type\u2010C retrovirus. human T\u2010Cell leukemia\u2010Lymphoma virus, in adult T\u2010Cell leukemia\u2010Lymphoma patients and healthy Blacks from the Caribbean","volume":"43","author":"Schupbach J.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_26_1","volume-title":"History of Sado voyage","author":"Tachibana M.","year":"1947"},{"key":"e_1_2_1_27_1","first-page":"893","article-title":"Epidemiological analysis of the distribution of antibody to adult T\u2010Cell leukemia\u2010Virus\u2010Associated antigen: possible horizontal transmission of adult T\u2010Cell leukemia virus","volume":"73","author":"Tajima K.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_28_1","volume-title":"History of Sado exiles","author":"Tanaka K.","year":"1975"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1182\/blood.V62.4.758.758","article-title":"A proposal for smoldering adult T\u2010Cell leukemia: a clinicopathologic study of five cases","volume":"62","author":"Yamaguchi K.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300306"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320304"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910350304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910350304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T22:14:18Z","timestamp":1697840058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910350304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3,15]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3,15]]}},"alternative-id":["10.1002\/ijc.2910350304"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910350304","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3,15]]}}}