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In the present study, the behaviour of ACPI\u2010immunoreactive DRC in reactive lymphoid secondary follicles and neoplastic follicles of follicular\u2010centre cell (FCC) lymphomas was compared by the peroxidase\u2010antiperoxidase method. The secondary follicles in reactive lymphoid tissues revealed a staining pattern characteristic of DRC comparable with the results of other studies. Contrary to this, the number of ACPI\u2010positive DRC in the neoplastic lymphoid follicles was greatly reduced. This was occasionally accompanied by a weak reaction and in many cases the DRC were totally abolished. Moreover, morphological aberrations were observed in ACPI\u2010positive DRC, especially diminution and shortening of dendritic processes. On occasion, ACPI\u2010positive cell types were observed, which may represent intermediate forms between DRC and fibroblastic reticulum cells. Only one case\u2010with a rather favourable clinical outcome (out of 41 follicular FCC lymphomas) exhibited an ACPI\u2010positive DRC pattern comparable with that of reactive lymphoid follicles. Thus it seems that the ACPI\u2010immunohistochemistry of DRC provides an additional tool for discerning the difference between reactive and neoplastic lymphoid follicles. This method is of particular value since it can be used with formalin\u2010fixed, paraffinembedded tissues. There was a tendency among the follicular FCC lymphoma patients towards a better survival rate for those with ACPI\u2010positive DRC than for those lacking this cell type, although no statistically significant differences emerged from this limited material.<\/jats:p>","DOI":"10.1002\/ijc.2910350307","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:15:44Z","timestamp":1171916144000},"page":"319-325","source":"Crossref","is-referenced-by-count":20,"title":["Behaviour of dendritic reticulum cells possessing immunoreactive acid cysteine\u2010proteinase inhibitor in human lymphoid secondary follicles and in follicular\u2010centre cell lymphomas"],"prefix":"10.1002","volume":"35","author":[{"given":"M.","family":"Alavaikko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Aine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rinne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Apaja\u2010Sarkkinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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