{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:23:36Z","timestamp":1759332216922},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":7764,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1985,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumour cell lines were established <jats:italic>in vitro<\/jats:italic> from 16 cases of Epstein\u2010Barr (EB) virus genome\u2010positive Burkitt's lymphoma (BL), 7 of \u201cendemic\u201d origin (<jats:italic>i.e.<\/jats:italic> from holoendemic malarial areas of Africa and of New Guinea) and 9 of \u201csporadic\u201d origin (<jats:italic>i.e.<\/jats:italic> from outside such high\u2010incidence areas). All the BL cell lines thus established were monoclonal by immunoglobulin iso\u2010type expression and displayed a characteristic chromosomal translocation, t(8:14) or t(8:22), confirming their malignant origin. Clear differences observed between the individual BL cell lines appeared to be related to their endemic or sporadic status. All 7 endemic cell lines began growth as a carpet of single cells, often with small, loose cumps appearing in later passage. Whilst 3 lines of sporadic origin displayed a similar pattern to the above, the majority of sporadic lines grew as large, tight clumps of cells from the first passage onwards. These differences in growth pattern were reflected by differences in cell surface phenotype, as defined in indirect immunofluorescence tests using a panel of monoclonal antibodies (MAbs) specific for B\u2010lineage\u2010associated antigens. BL cell lines could be classified into 3 separate groups on the basis of their reactivity with 6 particular antibodies (MHM6, AC2, Ki\u20101, Ki\u201024, J5 and 38.13). All 7 endemic BL cell lines and 2 of the 3 sporadic BL cell lines which began growth as single cells showed a group\u2010I cell\u2010surface phenotype (MHM6, AC2, Ki\u20101, Ki\u201024 negative; J5, 38.13 positive) in early passage. In contrast, all 6 sporadic BL cell lines which began growth in large clumps displayed a distinct group\u201011 phenotype (MHM6, AC2, Ki\u20101 positive\/negative; Ki\u201024, J5, 38.13 positive); in later passage most of these sporadic lines progressed to a group\u2010III phenotype (MHM6, AC2, Ki\u20101, Ki\u201024 positive; J5, 38.13 negative) without loss of those immunoglobulin and chromosomal markers identifying the cells' malignant origin. These clear differences between endemic BL cell lines on the one hand and the majority of sporadic BL cell lines on the other suggest that endemic BL arises from a more restricted range of progenitor B cells than does the sporadic form of the disease.<\/jats:p>","DOI":"10.1002\/ijc.2910350404","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:14:07Z","timestamp":1171916047000},"page":"435-441","source":"Crossref","is-referenced-by-count":97,"title":["Distinctions between endemic and sporadic forms of epstein\u2010barr virus\u2010positive burkitt's lymphoma"],"prefix":"10.1002","volume":"35","author":[{"given":"M.","family":"Rowe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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