{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:16:48Z","timestamp":1697991408486},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7763,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1985,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraperitoneal implantation of V2 carcinoma cells in the rabbit leads to invasion of the mesentery and to structural tissue alterations which are concomitantly of a destructive and a desmoplastic type. In this report, we describe the desmoplastic changes which are characterized by the increased formation of collagen and of proteoglycans resulting in an increased thickness of the membrane. Biochemical data indicate that the total amount of collagen increases with time after implantation, whereas the relative amount per unit of dry weight, as well as the contributions of type I (15\u201325%) and type III (6\u20138%), stay within the same range. The increased synthesis of extracellular matrix is accompanied by a change in the appearance of the fibroblasts which now show the morphologic features of synthesizing cells. Also, an appreciable number have entered the S\u2010phase. We propose that the desmoplastic changes are tumor\u2010associated, since implantation of epithelial cells from normal rabbit liver does not result in similar alteration. Our findings are discussed in view of the role played by tumor and\/or host cells in the increased production of extracellular matrix, of possible factor(s) elaborated by the tumor cells, and of the general significance of desmoplastia for tumor spread.<\/jats:p>","DOI":"10.1002\/ijc.2910350417","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:14:07Z","timestamp":1171916047000},"page":"527-534","source":"Crossref","is-referenced-by-count":7,"title":["Tumor\u2010associated desmoplasia in the rabbit mesentery characterized by morphological, biochemical and cytophotometric methods"],"prefix":"10.1002","volume":"35","author":[{"given":"G.","family":"Haemmerli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"M\u00fcller\u2010Glauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Hauser\u2010Urfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Str\u00e4uli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1975.112"},{"key":"e_1_2_1_3_1","first-page":"242","volume-title":"Problems in breast pathology","author":"Azzopardi J. G.","year":"1979"},{"key":"e_1_2_1_4_1","first-page":"276","article-title":"Increased content of type V collagen in desmoplasia of human breast carcinoma","volume":"108","author":"Barsky S. H.","year":"1982","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.004521"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(81)90204-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)50750-8"},{"key":"e_1_2_1_8_1","first-page":"335","article-title":"Human breast carcinoma: fibrin deposits and desmoplasia. Inflammatory cell type and distribution. Microvasculature and infarction","volume":"67","author":"Dvorak H. F.","year":"1981","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_9_1","first-page":"81","article-title":"Observation on collagenous stroma formation and desmoplastic breast carcinoma","volume":"20","author":"Groniowski J.","year":"1975","journal-title":"An. Med. Sect. Pol. Acad. Sci."},{"key":"e_1_2_1_10_1","first-page":"4543","article-title":"Stimulation of thymidine uptake and cell proliferation in mouse embryo fibroblasts by conditioned medium from mammary cells in cultures","volume":"36","author":"Howard E. F.","year":"1976","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(82)90036-3"},{"key":"e_1_2_1_12_1","first-page":"2168","article-title":"Neoplastic\u2010mesenchymal cell interaction: effects on proteoglycan biosynthesis and cell proliferation","volume":"41","author":"Iozzo R. V.","year":"1983","journal-title":"Fed. Proc."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80326-3"},{"key":"e_1_2_1_14_1","first-page":"124","article-title":"Proteoglycan changes in the intercellular matrix of human colon carcinoma","volume":"47","author":"Iozzo R.","year":"1982","journal-title":"Lab. Invest."},{"key":"e_1_2_1_15_1","first-page":"721","article-title":"Glycosaminoglycans of rat colorectal adenocarcinoma","volume":"73","author":"Isemura M.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700740203"},{"key":"e_1_2_1_17_1","first-page":"109","article-title":"The matrix of human breast tumor cells is mitogenic for fibroblasts","volume":"115","author":"Kao R. T.","year":"1984","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_18_1","first-page":"112","article-title":"Tumor extracellular matrix","volume":"47","author":"Liotta L. A.","year":"1982","journal-title":"Lab. Invest."},{"key":"e_1_2_1_19_1","first-page":"636","article-title":"Tumor invasion and the extracellular matrix","volume":"49","author":"Liotta L. A.","year":"1983","journal-title":"Lab. Invest."},{"key":"e_1_2_1_20_1","first-page":"665","volume-title":"Pathology","author":"Meissner W. A.","year":"1977"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340418"},{"key":"e_1_2_1_22_1","unstructured":"Necom S. R. An oat cell carcinoma tissue culture produces a growth factor(s) for fibroblasts.Amer. Assoc. Cancer Res. Abstracts226\/57 Washington D.C. (1981.)"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00048966"},{"key":"e_1_2_1_24_1","first-page":"3269","article-title":"Collagen synthesis by cloned mouse mammary tumor cells","volume":"38","author":"Roesel R. A.","year":"1978","journal-title":"Cancer Res."},{"key":"e_1_2_1_25_1","unstructured":"Ruch F. andTrapp L. Ein Mikroskopfluorometer mit Kurz\u2010zeit\u2010Anre\u2010gung und Schaltfolgesteuerung.Zeiss Inform. 81 Zeiss Oberkochen F.R.G. (1972.)"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(77)90093-9"},{"key":"e_1_2_1_27_1","first-page":"5403","article-title":"Morphological studies on V2 carcinoma invasion and tumor\u2010associated connective tissue changes in the rabbit mesentery","volume":"43","author":"Str\u00e4uli P.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(76)80180-5"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.12.6299"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197601)37:1<307::AID-CNCR2820370141>3.0.CO;2-C"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197903)43:3<1148::AID-CNCR2820430355>3.0.CO;2-N"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910350417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910350417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:49:38Z","timestamp":1697824178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910350417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4,15]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,4,15]]}},"alternative-id":["10.1002\/ijc.2910350417"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910350417","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4,15]]}}}