{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:28:51Z","timestamp":1789594131252,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7672,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1985,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukemic cells of adult T\u2010cell leukemia (ATL) patients contain human T\u2010cell leukemia virus type I (HTLV\u2010I) genomes. However, viral antigens (HTLV\u2010A) are not usually expressed <jats:italic>in vivo<\/jats:italic>. It has been shown that HTLV\u2010I antigens are spontaneously induced after culture of peripheral blood lymphocytes (PBL) from patients with ATL and healthy carriers (HC), who are viral antibody\u2010positive. In the present communication, we show the suppressive effect of human serum antibodies against HTLV\u2010I on viral antigen expression in PBL derived from ATL patients and HC. Viral antigen synthesis in various PBL specimens is variable in terms of frequencies and kinetics. (I) Low concentrations (2%) of antibody\u2010positive but not of antibody\u2010negative sera efficiently suppressed HTLV antigen induction in lymphocytes from both ATL patients and HC. (2) An inhibitory effect was exerted by HTLV\u2010I\u2010specific antibodies which originated from either ATL, HC or even HTLV\u2010I\u2010positive monkeys. (3)Sera showed a fairly wide range of suppressive activity in view of their wide range of suppressive activity in view of their concentrations. (4) At the late stage of cultures even continuous presence of antibodies frequently failed to suppress antigen synthesis in lymphocytes. (5) Antibodies were less effective in suppressing the increase of antigens if they were added to cultures which had already HTLV\u2010A\u2010positive lymphocytes in antibody\u2010free media. (6) Pretreatment with protein A completely abolished the activities of the suppressive plasmas. (7) Antibodies did not affect the inhibition of spontaneous or chemical induction of HTLV\u2010A in 2 HTLV\u2010I\u2010positive cell lines. These results suggest that HTLV\u2010I antigen expression in leukemic cells from patients with ATL <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> is partly regulated by antibodies to HTLV\u2010I. Furthermore, at least 2 different pathways, one antibody\u2010sensitive and the other \u2010insensitive, might exist to express HTLV\u2010A.<\/jats:p>","DOI":"10.1002\/ijc.2910360102","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:12:54Z","timestamp":1171915974000},"page":"1-7","source":"Crossref","is-referenced-by-count":31,"title":["Effect of human serum anti\u2010htlv antibodies on viral antigen induction in <i>In vitro<\/i> cultured peripheral lymphocytes from adult T\u2010CELL leukemia patients and healthy virus carriers"],"prefix":"10.1002","volume":"36","author":[{"given":"Tadafumi","family":"Tochikura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Iwahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorio","family":"Hinuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noaki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4123.422"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_2_1_4_1","first-page":"987","article-title":"Antigenic properties of experimental leukemias. II. Immunological studies in vivo with C57BL\/6 radiation\u2013induced Leukemias","volume":"31","author":"Boyse E. A.","year":"1963","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.15.4780"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91885-8"},{"key":"e_1_2_1_7_1","first-page":"341","article-title":"A retrovirus associated with human adult T\u2010cell leukemia: in vitro activation","volume":"73","author":"Hinuma Y.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290606"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.19.6061"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320311"},{"key":"e_1_2_1_12_1","first-page":"155","article-title":"A novel T\u2010cell line derived from adult T\u2010cell leukemia","volume":"71","author":"Miyoshi I.","year":"1980","journal-title":"Gann"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/294770a0"},{"key":"e_1_2_1_14_1","first-page":"978","article-title":"A T\u2010cell line derived from normal human cord leukocytes by co\u2010culturing with human leukemic T\u2010cells","volume":"72","author":"Miyoshi I.","year":"1981","journal-title":"Gann"},{"key":"e_1_2_1_15_1","first-page":"332","article-title":"Asymptomatic type C virus carriers in the family of an adult T\u2010cell leukemia patient","volume":"73","author":"Miyoshi I.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/294268a0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.17.5402"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/147.3.399"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.4049\/jimmunol.125.4.1506","article-title":"Modulation of human acute lymphoblastic leukemia antigen induced by monoclonal antibody in vitro","volume":"125","author":"Ritz J.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90086-2"},{"key":"e_1_2_1_22_1","first-page":"327","article-title":"Monoclonal antibody reactive with both p28 and p19 of adult T\u2010cell leukemia virus\u2010specific polypeptides","volume":"74","author":"Tanaka Y.","year":"1983","journal-title":"Gann"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T cell leukemia: clinical and hematological features of 16 cases","volume":"50","author":"Uchiyama T.","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90446-X"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300306"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6980467"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1515\/znc-1982-7-828","article-title":"Adult T\u2010cell leukemia\u2010associated antigen (ATLA): detection of a glycoprotein in cell\u2010 and virus\u2010free supernatant","volume":"37","author":"Yamamoto N.","year":"1982","journal-title":"Z. Nuturforsch."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910320304"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2534"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330606"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910360102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910360102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:31:35Z","timestamp":1697833895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910360102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7,15]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,7,15]]}},"alternative-id":["10.1002\/ijc.2910360102"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910360102","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,7,15]]}}}