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The anticomplement immunofluorescence (ACIF) staining detects an EBV\u2010specific nuclear reaction that has recently been shown to be due to at least 2 different proteins, EBNA\u20101 and EBNA\u20102, encoded by different parts of the viral genome. We now report the existence of a third antigen of the EBNA complex, designated as EBNA\u20103. Serum from a patient with chronic infectious mononucleosis contained no detectable antibodies to EBNA\u20101 and had only a low EBNA\u20102 antibody level. Nevertheless, it gave an EBV\u2010specific nuclear reaction of normal intensity and stained EBNA\u20102\u2010positive and EBNA\u20102\u2010negative EBV\u2010carrying lines equally well. Immunoblotting with the same serum identified a new EBV\u2010specific nuclear protein of 143\u2010157 kDa.<\/jats:p>","DOI":"10.1002\/ijc.2910370205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:24:37Z","timestamp":1171916677000},"page":"195-200","source":"Crossref","is-referenced-by-count":21,"title":["The Epstein\u2010Barr virus determined nuclear antigen is composed of at least three different anitgens"],"prefix":"10.1002","volume":"37","author":[{"given":"Joakim","family":"Dillner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Kallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbro","family":"Ehlin\u2010Henriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rymo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Henle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrude","family":"Henle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(85)90253-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190105"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.13.4183"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.23.7632"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/jvi.27.1.81-89.1978","article-title":"Heterogeneity of Epstein\u2010Barr virus. 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