{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T21:39:41Z","timestamp":1744148381900},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7398,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1986,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic studies were performed on 11 Japanese patients with adult T\u2010cell lymphoma of peripheral T\u2010cell origin. All patients had a histologic diagnosis of diffuse lymphoma, and were treated with intensive combination chemotherapy; their median survival was 6 months. Lymphomas were categorized on the basis of the classification proposed by the Lymphoma Study Group of Japan: 5 patients had the features of pleomorphic lymphoma; 3, mixed lymphoma; 2, large\u2010cell lymphoma; and 1, medium\u2010sized\u2010cell lymphoma. The modal chromosome number of abnormal cells was near\u2010diploid in 7, and hypotetraploid in 4 including 3 patients with pleomorphic lymphoma. Abnormalities of the clonal chromosomes were observed in all 11 patients. A translocation of the short arm of 19 at band 19p13 was found in 2 patients with pleomorphic lymphoma and in one patient each with mixed lymphoma and medium\u2010sized\u2010cell lymphoma. A transloction of the short arm of 14, with a break at band 14p12, occurred in 4 patients with pleomorphic lymphoma. In one patient each with mixed lymphoma and large\u2010cell lymphoma, an extra chromosome 3 was found. The numerical change was unique because their lymphomas were further categorized as \u201cangioimmunoblastic lymphadenopathy with dysproteinemia\u201d and \u201clarge\u2010cell immunoblastic lymphoma\u201d, respectively. Our findings suggest that characteristic chromosome abnormalities occur in adult T\u2010cell lymphoma, and dividing cells in the tetraploid range tend to be precominant in pleomorphic lymphoma.<\/jats:p>","DOI":"10.1002\/ijc.2910370408","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:21:25Z","timestamp":1171916485000},"page":"517-524","source":"Crossref","is-referenced-by-count":30,"title":["Recurrent chromosome abnormalities in adult T\u2010cell lymphomas of peripheral T\u2010cell origin"],"prefix":"10.1002","volume":"37","author":[{"given":"Kazuyuki","family":"Fujita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirou","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Nasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Yamabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Tomono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Inamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Shimazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kamksaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Ueshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruto","family":"Uchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2975","article-title":"Nonrandom chromosome abnormalities in lymphoma","volume":"43","author":"Bloomfield C. 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