{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:03:08Z","timestamp":1791655388217,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1986,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six healthy relatives of 3 adult T\u2010cell leukemia lymphoma (ATLL) patients and 6 members of a Caribbean family immigrant to the UK have been investigated for the presence of HTLV\u2010I and expression of interleukin 2 (IL\u20102) receptors. Serum antibodies to HTLV\u2010I were detected in all but 4 samples. Four to 10% of circulating cells from 3\/4 seropositive donors studied displayed IL\u20102 receptors (anti\u2010Tac+) and were shown to be convoluted lymphocytes by light microscopy morphology and immunoelectronmicroscopy. After 5 to 28 days in culture, cells from 4 seropositive donors reacted with monoclonal antibodies (MAbs) against the HTLV\u2010I core proteins, p19 and p24, and released retrovirus particles. Similar experiments with blood from 3 seronegative donors from the same families and 4 normal controls proved negative. Our findings indicate that seropositive individuals harbour the virus in a population of T\u2010lymphocytes which may then acquire receptors for IL\u20102. These individuals are at risk of developing ATLL.<\/jats:p>","DOI":"10.1002\/ijc.2910380108","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:20:24Z","timestamp":1171916424000},"page":"41-45","source":"Crossref","is-referenced-by-count":27,"title":["Studies in healthy human T\u2010cell\u2010leukemia lymphoma virus (HTLV\u2010I) carriers from the Caribbean"],"prefix":"10.1002","volume":"38","author":[{"given":"E.","family":"Matutes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Dalgleish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6320374"},{"key":"e_1_2_1_3_1","unstructured":"Blattner W. A. Clark J. W. Gibbs W. N. Jaffe E. S. Robert\u2010Guroff M. Saxinger W. C. andGallo R. C. Human T\u2010cell leukemia\/lymphoma virus: epidemiology and relationship to human malignancy.In: R. C. Gallo M. E. Essex and L. Gross (eds.) Human T\u2010cell leukemia\/lymphoma virus pp.267\u2013274 Cold Spring Harbor New York (1984)."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92200-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6316502"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90306-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1182\/blood.V61.1.205.205","article-title":"Chromosome aberrations in T lymphocytes carrying adult T\u2010cell\u2010leukemia\u2010associated antigens (ATLA) from healthy adults","volume":"61","author":"Fukuhara Sh.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_9_1","unstructured":"GALLO R. C. ESSEX M. E. and GROSS L. (eds.) Human T\u2010cell leukemia\/lymphoma virus. 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Monoclonal antibodies against human T\u2010cell leukemia\/lymphoma virus p19 and p24 internal core proteins: spectrum of normal tissue reactivity and use as diagnostic probes.In: R. C. Gallo M. E. Essex and L. Gross (eds.) Human T\u2010cell leukemia\/lymphoma virus pp.197\u2013203 Cold Spring Harbor New York (1984).","DOI":"10.1084\/jem.159.4.1117"},{"key":"e_1_2_1_15_1","first-page":"341","article-title":"A retrovirus associated with human adult T\u2010cell leukemia: in vitro activation","volume":"73","author":"Hinuma Y.","year":"1982","journal-title":"Gann"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290606"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1182\/blood.V66.1.120.120","article-title":"Preleukemic state of adult T\u2010cell leukemia: abnormal T lymphocytosis induced by human adult T cell leukemia\/lymphoma virus","volume":"66","author":"Kinoshita K.","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/305733a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.4049\/jimmunol.131.4.2021","article-title":"Cell surface antigen expression in new\u2010born cord blood lymphocytes infected with HTLV","volume":"131","author":"Mann D. 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V. Suppressor cells within the activated OKT4+ population belong to a distinct subset","volume":"128","author":"Thomas Y.","year":"1982","journal-title":"J. Immunol."},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.4049\/jimmunol.126.4.1398","article-title":"A monoclonal antibody (anti\u2010Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells and one of two types of helper T cells","volume":"126","author":"Uchiyama T.","year":"1981","journal-title":"J. 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