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The lymphoid patches of DMH\u2010treated rats and of 14 untreated control animals were systematically studied histologically on sections of \u201cswiss\u2010rolled\u201d whole intestine. It was found that 78% of the small\u2010intestine carcinomas and 73% of the colorectal carcinomas were associated with intestinal lymphoid patches. Furthermore, misplaced and often atypical glandular crypts were often found in the parafollicular or interfollicular areas of lymphoid patches, in treated as well as in control animals. These glands could be the origin of the lymphoid\u2010patch\u2010associated carcinoma. Immunohistological staining with monoclonal antibodies (MAbs) against T\u2010lymphocyte antigens or anti\u2010IgM serum labelling B lymphocytes clearly localized early carcinoma and atypical glands in the T\u2010dependent, interfollicular and parafollicular area of lymphoid follicles. An MAb directed against la\u2010antigen stained some well\u2010differentiated carcinomas and some atypical glands found in control rats. On the other hand, lymphoid patches, when not invaded by a carcinoma, were not modified in their number, size, morphology or cellular composition in DMH\u2010treated rats as compared to control animals.<\/jats:p>","DOI":"10.1002\/ijc.2910380113","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:20:24Z","timestamp":1171916424000},"page":"75-80","source":"Crossref","is-referenced-by-count":23,"title":["Gut\u2010associated lymphoid tissue and 1,2\u2010dimethylhydrazine intestinal tumors in the rat: An histological and immunoenzymatic study"],"prefix":"10.1002","volume":"38","author":[{"given":"M. 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