{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:18:03Z","timestamp":1759580283752},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7276,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1986,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010cell leukemia\/lymphoma virus 1 (HTLV\u20101) is known to be associated with adult T\u2010cell leukemia\/lymphoma (ATL) as an etiological agent. The mechanism of leukemogenesis by HTLV, however, is still obscure. Two hypotheses have been proposed concerning abnormalities in 1L\u20102 production and its receptor (Tac antigen) expression based on the experimental observations of 1L\u20102\u2010dependent ATL cell lines. In this study, we examine these hypotheses by using 3 leukemic T\u2010cell lines from 3 Japanese patients with ATL. These cell lines were cultivated and established without addition of 1L\u20102 to the culture medium. Cell\u2010surface phenotype analysis by immunofluorescence with monoclonal antibodies (MAbs) and 1L\u20102 binding assays revealed that one of the ATL cell lines, HPB\u2010ATL\u20102, expresses only a minimal amount of 1L\u20102 receptor (1L\u20102\u2010R) on the cell surface and binds less radiolabelled human recombinant 1L\u20102 than the other highly Tac\u2010positive cell lines. Expression of Tac antigen in all ATL cell lines was not affected by 1L\u20102, anti\u2010Tac MAb or the tumor\u2010promoter phorbol ester in the culture medium. The culture supernatant from these cell lines showed no 1L\u20102 activity toward Con\u2010A\u2010stimulated human peripheral blood lymphocytes, and their growth was not affected by additional 1L\u20102 in cultures. 1L\u20102\u2010independent growth and constitutive expression of its receptors on the cell surface were evident in our ATL cell lines. However, dense expression of 1L\u20102 receptors was not essential for stimulation of leukemic proliferation of T cells by HTLV\u2010I. Trans\u2010activation of the PX\u2033 gene product of HTLV\u2010I for activation of 1L\u20102\u2010R gene might not be coincidentally associated with stimulation for cell proliferation.<\/jats:p>","DOI":"10.1002\/ijc.2910380218","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:18:30Z","timestamp":1171916310000},"page":"265-274","source":"Crossref","is-referenced-by-count":24,"title":["IL\u20102\u2010 and IL\u20102\u2010R\u2010 independent proliferation of T\u2010cell lines from adult T\u2010cell leukemia\/lymphoma patients"],"prefix":"10.1002","volume":"38","author":[{"given":"Taiji","family":"Katoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Morkawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Wakutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6320374"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1001\/jama.1983.03340080026022","article-title":"The human T\u2010cell leukemia\/lymphoma virus (HTLV) in the southeastern United States","volume":"250","author":"Blayney D. 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