{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T05:21:00Z","timestamp":1698384060710},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7245,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1986,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The DMA configuration of the immunoglobulin (Ig) heavy and light chain genes and the expression of B\u2010 cell\u2010related markers were evaluated in 13 cases of non\u2010 T, non\u2010B, non\u2010common (\u201cnull\u201d) acute lymphoblastic leukaemia (ALL). A rearrangement of the Ig heavy\u2010 chain gene was found in all cases studied; in 5 of these a structural reorganization of the <jats:italic>K<\/jats:italic> or \u039b light chain gene was also demonstrated. Leukaemic cells from 10 of the 13 cases analysed showed one or more B\u2010cell antigens, the expression of which followed a sequential order of presentation (OKB2, B4, BA\u20101, B1). The B\u2010cell commitment was confirmed by means of a sensitive immunoperoxidase assay which revealed a weak expression of the common ALL (cALL) antigen in 7\/10 cases tested, which were all cALL\u2010negative by conventional immunofluorescence techniques. These findings suggest that in \u201cnull\u201d ALL the neoplastic cells show molecular and immunological evidence of B\u2010cell differentiation and that most cases may indeed be characterized by \u201cearly\u201d cALL with a very low density expression of the cALL antigen. This was further documented in one case in which the expression of the cALL antigen (and of other B\u2010cell markers) could be induced after exposure to 12\u2010O\u2010tetradecanoylphorbol\u2010 13\u2010acetate (TPA). The presence in a few cases of myeloid features, particularly when the cALL antigen could not be demonstrated by the immunoperoxidase assay, suggests that the leukaemic process may sometimes involve a very early progenitor cell capable of both lymphoid and myeloid phenotypic differentiation. The heterogeneity of \u201cnull\u201d ALL documented by this study may help to explain the variable clinical course and prognosis of these patients.<\/jats:p>","DOI":"10.1002\/ijc.2910380304","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:17:56Z","timestamp":1171916276000},"page":"317-323","source":"Crossref","is-referenced-by-count":13,"title":["Molecular and immunological evidence of B\u2010cell commitment in \u201cnull\u201d acute lymphoblastic leukaemia"],"prefix":"10.1002","volume":"38","author":[{"given":"R.","family":"Foa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Migone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Basso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cattoretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pizzolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lauria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Casorati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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