{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:58:46Z","timestamp":1752361126423},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7245,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1986,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The interactions of nude mouse macrophages with five human melanoma cell lines, characterized by their resistance to mouse NK activity and varying in their ability to grow s.c. in nude mice, were investigated. These lines were equally susceptible <jats:italic>in vitro<\/jats:italic> to both cytostatic and tumoricidal activities of activated peritoneal macrophages collected from nude mice inoculated 3 days previously with <jats:italic>Brucella abortus<\/jats:italic> B19R strains, I.p. injection of a poorly tumorigenic melanoma cell line (PTCL) in nude mice was followed by the local appearance of macrophages able to kill these cells in a 48\u2010hr <jats:sup>3<\/jats:sup>H\u2010thymidine cytotoxicity assay. The level of tumoricidal macrophages was maximum for the first week and then slowly declined to disappear by the 4th week following PTCL inoculation. The use of an HTCL instead of a PTCL also induced macrophages able to kill HTCL cells, but the cytotoxicity level was lower and the activity disappeared more rapidly. In cross\u2010experiments using PTCL\u2010activated macrophages as effectors on HTCL targets, these cells were found to be less sensitive than PTCL cells when macrophages were taken at weeks 2 and 3 following PTCL inoculation. To investigate whether tumoricidal macrophages activated <jats:italic>In vivo<\/jats:italic> with human melanoma cells could also act <jats:italic>in vivo<\/jats:italic>, we inoculated these s.c. into nude mice, simultaneously with live HTCL cells. Peritoneal cells rich in melanoma\u2010activated macro\u2010phages prevented HTCL growth in most recipients, whereas spleen cells from the same donor mice did not modify the tumor take. These data indicate that xenogeneic tumors could activate nude mouse macrophages <jats:italic>in vivo<\/jats:italic> and suggest that the ability of human tumors to grow in nude mice could be related to their capacity to activate host macrophages locally and to the susceptibility of human tumor cells to the tumoricidal activity of activated macrophages.<\/jats:p>","DOI":"10.1002\/ijc.2910380318","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:17:56Z","timestamp":1171916276000},"page":"419-424","source":"Crossref","is-referenced-by-count":4,"title":["Interactions with host macrophages and ability of human melanoma cell lines to grow in nude mice"],"prefix":"10.1002","volume":"38","author":[{"given":"Abdeljalil","family":"Benomar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Gerlier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Franc\u0328ois","family":"Dor\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"904","article-title":"Macrophage production in response to the growth of an experimental tumour","volume":"59","author":"Baum M.","year":"1972","journal-title":"Brit. 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