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By the freeze\u2010fracture technique, intramembrane particles (IMPs) are quantified in B lymphocytes following Epstein\u2010Barr virus (EBV) transformation <jats:italic>in vitro<\/jats:italic>, and in B\u2010lymphoma (Burkitt\u2010type) cells, either positive or negative for EBV genome. Analysis shows an overall increase in IMP density as compared to normal controls. Differences are observed between the protoplasmic and exoplasmic faces of fractured membranes as well as among <jats:italic>in vitro<\/jats:italic> transformed and clearly neoplastic cells. 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