{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:51:47Z","timestamp":1790524307112,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1986,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell lines established from T\u2010cell leukemias have recently been reported to exhibit a chromosome translocation t(8;14) involving proto\u2010oncogene <jats:italic>c\u2010myc<\/jats:italic> and the gene of the T\u2010cell receptor \u03b1\u2010chain(TcR\u2010\u03b1). In this work, we have studied a case of T\u2010cell leukemia presenting a t(8;14)(q24;q11) translocation that was found in fresh Jeukemic cells taken during relapse, but was absent in cells collected at diagnosis. Hybridization analysis showed that the breakpoint on chromosome 8 was located 3\u2032 to the <jats:italic>c\u2010myc<\/jats:italic> exon 3. A TcR\u2010\u03b1\u2010specific original probe (D14S7, Mathieu\u2010Mahul <jats:italic>et al.<\/jats:italic>, 1985) revealed two differently rearranged patterns in DNA from leukemic cells obtained at diagnosis and during relapse. In contrast, the rearranged TcR\u2010\u03b2\u2010gene DNA pattern did not change during the course of the disease, indicating that leukemic cells were clonally related. These data indicate that the chromosome breakpoint in 14q11 is situated in the TcR\u2010\u03b1 locus. These results suggest that translocations t(8;14) involving TcR\u2010\u03b1 and <jats:italic>c\u2010myc<\/jats:italic> genes in T\u2010cell malignancies are analogous to variant t(2;8) and t(8;22) translocations observed in Burkitt lymphoma. They also establish that the same types of molecular rearrangements due to a t(8;14) (q24;q11) translocation, at first described in T\u2010cell lines established in culture, also exist <jats:italic>in vivo<\/jats:italic> and may play a role in the evolution of the leukemic process.<\/jats:p>","DOI":"10.1002\/ijc.2910380609","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:47:12Z","timestamp":1171918032000},"page":"835-840","source":"Crossref","is-referenced-by-count":26,"title":["A t(8;14)(q24;q11) translocation in a T\u2010cell leukemia (L1\u2010all) with <i>c\u2010myc<\/i> and TcR\u2010alpha chain locus rearrangements"],"prefix":"10.1002","volume":"38","author":[{"given":"Dani\u00e8le","family":"Mathieu\u2010Mahul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Sigaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Bernheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Mauchauffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian\u2010Jacques","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00344a005"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_4_1","series-title":"IARC Scientific Publication No. 60","first-page":"65","volume-title":"Burkitt's lymphoma: a human cancer model","author":"Berger R.","year":"1985"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7571"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/317443a0"},{"key":"e_1_2_1_7_1","first-page":"171","article-title":"Remaniement du locus du proto\u2010oncog\u00e8ne c\u2010myc dans une lign\u00e9e cellulaire d'origine lymphoblastique","volume":"300","author":"Caubet J. F.","year":"1985","journal-title":"C. R. Acad. Sci. (Paris)"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V65.1.1.1","article-title":"A molecular basis of human B\u2010cell neoplasia","volume":"65","author":"Croce C. M.","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.22.7046"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"Eick D. Piechacyzk M. Henglein B. Blanchard J. M. Traub B. Kofler E. Wiest S. Lenoir G. andBornkamm W. Aberrantc\u2010mycRNAs of Burkitt's lymphoma cells have longer half\u2010lives.Europ. mol. Biol. Org. 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H.","year":"1985","journal-title":"Europ. mol. Biol. Org. J."},{"key":"e_1_2_1_25_1","first-page":"175","article-title":"Leuc\u00e9mie aigue lymphoblastique de type T avec translocation t(8;14)(q24;q72)","volume":"25","author":"Riviere D.","year":"1983","journal-title":"Nouv. Rev. Fran\u00e7. H\u00e9matol."},{"key":"e_1_2_1_26_1","first-page":"1413","article-title":"3\u2032 c\u2010myc rearrangement in a human leukemic t\u2010cell line","volume":"46","author":"Saglio G.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/305245a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.10.3439"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90381-7"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.18.120184.003005"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/303725a0"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90078-3"},{"key":"e_1_2_1_33_1","unstructured":"Zhu C. Sigaux F.;Miglierina R. Valensi F. Daniel M. T. Ochoa\u2010Noguera M. H. andFlandrin G. Immunological typing of acute lymphoblastic leukemia: concurrent analysis by flow cytofluorometry and immunocytology.Leukemia Res. (1986). In press."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910380609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910380609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T23:03:50Z","timestamp":1697843030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910380609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12,15]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,12,15]]}},"alternative-id":["10.1002\/ijc.2910380609"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910380609","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12,15]]}}}