{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:35:40Z","timestamp":1785209740119,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":7123,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1987,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have established 3 new EBV\u2010negative cell lines, designated Sc\u20101, Ri\u20101 and Ci\u20101, from patients with B\u2010cell lymphoma\/leukemia. We characterized them by cytogenetics and by study of surface membrane antigens with a panel of monoclonal antibodies (MAbs), surface and cytoplasmic immunoglobulin (1g) expression and 1g heavy\u2010 and light\u2010chain genes. A11 3 lines had a 14q+ abnormality. Ri\u20101 also had translocations involving chromosomes 2, 8 and 18. Ci\u20101 also had abnormalities involving chromosomes 2, 8 and 22 and its karyotype was 46, XX, t(2;8), t(14;22). The t(2;8) had the same breakpoints as those reported in some cases of Burkitt's lymphoma. We also studied a classical Ph<jats:sup>1<\/jats:sup>\u2010positive cell line previously established by Pegoraro <jats:italic>et al.<\/jats:italic> (1983) and designated BV173. The phenotypes of these 4 lines based on 1g expression and marker studies correlated well with their respective genotypes. Our results are in keeping with the notion that leukaemic cell populations are clonal expansions of cells \u201cfrozen\u201d at a particular stage in their differentiation. Specifically, BV173 cells are at an early stage of B\u2010cell differentiation, Ri\u20101 and Ci\u20101 cells are at intermediate stages and Sc\u20101 cells are at a relatively late stage in the B\u2010cell lineage.<\/jats:p>","DOI":"10.1002\/ijc.2910390116","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:47:04Z","timestamp":1171918024000},"page":"89-93","source":"Crossref","is-referenced-by-count":25,"title":["Establishment and characterization of three new malignant lymphoid cell lines"],"prefix":"10.1002","volume":"39","author":[{"given":"K. 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