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Helper T\u2010cell clones specific to EBV\u2010transformed B\u2010LCL were restricted either by class\u20101 or by class\u201011 HLA molecules of self. T\u2010cell clones restricted by class\u20101 HLA molecules were stained by OKT3 and OKT8 monoclonal antibodies (MAbs), whereas class\u201011\u2010restricted clones stained with OKT3 and OKT4. Not all helper T\u2010cell clones specific to EBV\u2010transformed B\u2010LCL were restricted to self: one clone restricted by allo\u2010HLA antigen was established. This finding suggests that in humans, as in mice, some T cells in the T\u2010cell repertoire can be allo\u2010restricted. This allo restriction may represent cross\u2010reactivity of T cells, whereby \u201cself + X\u201d equals \u201callo + Y.\u201d Activation of these cross\u2010reacting T cells restricted by allogeneic HLA molecules during infectious mononucleosis will give a T\u2010cell response which may appear unrestricted by self HLA molecules. This mechanism helps to explain, at least in part, the HLA unrestricted cytotoxicity to B\u2010LCL observed in infectious mononucleosis.<\/jats:p>","DOI":"10.1002\/ijc.2910390120","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:47:04Z","timestamp":1171918024000},"page":"111-117","source":"Crossref","is-referenced-by-count":5,"title":["Reactive T cells in the immune repertoire: Self\u2010restricted and allo\u2010restricted helper T\u2010cell clones to epstein\u2010barr virus"],"prefix":"10.1002","volume":"39","author":[{"given":"Patrick K.","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Pauza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara L.","family":"Switzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Purtilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/281307a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4049\/jimmunol.131.2.628","article-title":"The nature of the interaction between suppressor and helper T cells in response to LDHb","volume":"131","author":"Baxevanis C. 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