{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:54:20Z","timestamp":1758473660052},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6973,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1987,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr Virus (EBV) is associated with two malignant diseases, African Burkitt's Lymphoma (BL) and Undifferentiated Nasopharyngeal Carcinoma (UNPC). North Africa is a geographical area with a high incidence of NPC. Our purpose in this study was to explore cell\u2010mediated immunity of peripheral blood lymphocytes (PBL) from patients with UNPC and DNPC. We found an elevated percentage of OKT8 cells and of large granular lymphocytes (LGL) (30 \u2010 35% HNK\u2010I\u2010positive cells) compared to PBL from healthy matched individuals. PBL from NPC patients contained 35% HLA\u2010DR\u2010 positive and 30% Interleukin\u20102 (IL\u20102) receptor\u2010positive circulating lymphocytes. PBL from NPC patients exhibited a normal proliferative response to phytohemagglutinin (PHA) and Concanavalin A (Con A) and an increased response to pokeweed mitogen (PWM). Natural killer (NK) activity towards K562 cells was low in our patients who, in addition, exhibited no lytic activity against HLA\u2010matched EBV\u2010transformed B cells. This lack of cytotoxicity against an EBV\u2010transformed B\u2010cell line cannot be explained by an impairment of IL\u20102 secretion, and is probably a result of the presence of high numbers of OKT8 suppressor T cells.<\/jats:p>","DOI":"10.1002\/ijc.2910390602","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:43:02Z","timestamp":1171917782000},"page":"663-669","source":"Crossref","is-referenced-by-count":8,"title":["Presence of <i>in vivo<\/i>\u2010activated t\u2010cells expressing hla\u2010dr molecules and il\u20102 receptors in peripheral blood of patients with nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"39","author":[{"given":"M.","family":"Lakhdar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ellouz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kammoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ben H'Tira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Khedhiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kastally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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