{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:19:29Z","timestamp":1758637169732},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6972,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1987,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The c\u2010<jats:italic>yes<\/jats:italic>\u20101 and <jats:italic>bc1<\/jats:italic>\u20102 genes have been independently mapped at the same position of the chromosome band, 18q21.3, which is a breakpoint in the t(14; 18) chromosomal translocation. High\u2010molecular\u2010weight genomic DNAs and mRNA isolated from a follicular lymphoma cell line FL\u201018 and an Epstein\u2010Barr virus harboring FL\u201018EB cell line, which carried the t(14;18), were analyzed. Although there was no detectable c\u2010<jats:italic>yes<\/jats:italic> rearrangement, the chromosome 18\u2010specific probe b (<jats:italic>bc1<\/jats:italic>\u20102) revealed one rearranged fragment after <jats:italic>Eco<\/jats:italic>RI, <jats:italic>Bam<\/jats:italic>HI, <jats:italic>Pst<\/jats:italic>I and <jats:italic>Sst<\/jats:italic>I digestion. Therefore, breakage of chromosome 18 in the t(14;18) occurred at the <jats:italic>Sst<\/jats:italic>I fragment containing the probe b sequence on the <jats:italic>bc1<\/jats:italic>\u20102 gene. The transcript of c\u2010<jats:italic>yes<\/jats:italic> was undetectable, whereas active transcription of <jats:italic>bc1<\/jats:italic>\u20102 was observed in the FL\u201018 and FL\u201018EB cell lines at a higher level than in other types of lymphoma cell line. These data suggest that the c\u2010<jats:italic>yes<\/jats:italic>\u20101 is not involved in the t(14;18), and the 2 genes located at 18q21.3 are independent sequences.<\/jats:p>","DOI":"10.1002\/ijc.2910390622","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:43:02Z","timestamp":1171917782000},"page":"785-788","source":"Crossref","is-referenced-by-count":13,"title":["c\u2010<i>yes<\/i> and <i>bc1<\/i>\u20102 genes located on 18q21.3 in a follicular lymphoma cell line carrying a t(14;18) chromosomal translocation"],"prefix":"10.1002","volume":"39","author":[{"given":"Hitoshi","family":"Ohno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirou","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh\u2010Ichirou","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketoshi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruto","family":"Uchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumao","family":"Toyoshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80070-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/319238a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.1.315"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7439"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V65.1.1.1","article-title":"Molecular basis human B cell neoplasia","volume":"65","author":"Croce C. 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