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Using a panel of monoclonal antibodies (MAbs) identifying determinants expressed at the surface of normal plasma cells, and polyclonal antibodies against surface and cytoplasmic immunoglobulin, we have found that growth inhibition is accompanied by plasmacytoid differentiation. Assays of growth stimulation of heterologous cells indicate that the culture medium from interferon\u2010treated Daudi cells contains substantially more B\u2010cell growth factor activity than that from control cells. However, the interferon\u2010treated cells exhibit an impaired ability to respond to both these autocrine factors and exogenous factors produced by another Burkitt lymphoma line. These findings show that, in the case of Daudi cells, growth inhibition by interferons is closely associated with both terminal differentiation and a refractoriness to growth factors. In this system IFN\u2010\u03b1 may therefore be considered to be a B\u2010cell differentiation factor, suggesting a possible basis for the anti\u2010proliferative effects observed with certain human B\u2010cell malignancies.<\/jats:p>","DOI":"10.1002\/ijc.2910400110","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:54:42Z","timestamp":1171918482000},"page":"53-57","source":"Crossref","is-referenced-by-count":27,"title":["Anti\u2010proliferative effects of interferons on Daudiburkitt Lymphoma cells: Induction of cell differentiation and loss of response to autocrine growth factors"],"prefix":"10.1002","volume":"40","author":[{"given":"Ruth","family":"Exley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-28-2-207"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"13074","DOI":"10.1016\/S0021-9258(17)38840-3","article-title":"Inhibition of transferrin receptor expression by interferon\u2010 in human lymphoblastpid cells and mitogen\u2010Induced lymphocytes","volume":"260","author":"Besan\u010don F.","year":"1985","journal-title":"J. biol. 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