{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T12:36:25Z","timestamp":1720701385819},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6880,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1987,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Specific antibody responses against the 2 major subcomponents of EBNA, EBNAI and EBNA2 were evaluated, in order to study whether this serological study was beneficial compared to classical EBV serology. During this investigation, 491 sera, obtained from blood donors and patients with Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC), infectious mononucleosis (IM), Hodgkin's disease, renal transplantation, rheumatoid arthritis and Human Immunodeficiency Virus (HIV) infection, were tested. While the anti\u2010EBNAI response followed the classical anti\u2010EBNA\/Raji response (99% of anti\u2010EBNA\/Raji\u2010positive sera also recognize EBNAI), the anti\u2010EBNAI response was much less frequent and did not correlate with either anti\u2010EBNA\/Raji or anti\u2010EA antibodies. In a control population, 8% of individuals had anti\u2010EBNAZ antibodies at titers \u2265 10. The percentage was 45% In NPC and 38% in EBV\u2010associated BL; thus, although not detected in all patients with EBV\u2010associated tumors, anti\u2010EBNA2 serology might be a useful marker in BL and NPC. No antibody was detected in the early course of IM, but in rheumatoid arthritis and in HIV\u2010infected patients, the percentage of positive individuals reached 54 and 68, respectively. Seroconversion to EBNA2 was noted in a few cases, including renal transplant recipients, AIDS patients, and complicated IM. This suggests that in these situations, EBNA 2 serology might represent a useful marker related to modulation of the immune status or EBV reactivation.<\/jats:p>","DOI":"10.1002\/ijc.2910400311","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:09:48Z","timestamp":1171919388000},"page":"349-353","source":"Crossref","is-referenced-by-count":23,"title":["Antibody response against the Epstein\u2010Barr virus\u2010coded nuclear antigen2 (EBNA2) in different groups of individuals"],"prefix":"10.1002","volume":"40","author":[{"given":"J. M.","family":"Seigneurin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Lavoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Genoulaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. W.","family":"Bornkamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"196","article-title":"Epstein\u2010Barr virus\u2010Related antibody patterns in ataxia telangiectasia","volume":"35","author":"Berkel A. I.","year":"1979","journal-title":"Clin. exp. 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