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All EBV\u2010negative cell lines were LMP\u2010negative and 18 of 21 EBV\u2010carrying cells were LMP\u2010positive. LMP concentrations varied widely, ranging approximately from less than 4 ng up to 650 ng\/mg protein. In several instances comparisons were made between lymphoblastoid (LCLs) and Burkitt lymphoma (BL) cell lines (EBV\u2010positive or EBV\u2010co wetted sublines of originally EBV\u2010negative BL) originating from the same patient. In all such cases LMP and LMP\u2010specific mRNA levels were higher in the LCLs. Most of the LMP was found in the cytosol fraction, yet this fraction was negative in immunoblotting tests. However, antiserum preincubated with the cytosol lost its ability to react in immunoblotting with membrane LMP, indicating that the 2 LMP forms (membrane and cytosol) are completely cross\u2010reactive.<\/jats:p>","DOI":"10.1002\/ijc.2910400313","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:09:48Z","timestamp":1171919388000},"page":"358-364","source":"Crossref","is-referenced-by-count":26,"title":["Down\u2010regulation of the EBV\u2010encoded membrane protein (LMP) in burkitt lymphomas"],"prefix":"10.1002","volume":"40","author":[{"given":"A.","family":"Hatzubai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Anafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Masucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Dillner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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