{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:52:40Z","timestamp":1697892760107},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6850,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1987,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome analysis was performed on I patient with diffuse lymphoma of mixed type by histologic diagnosis and on 7 patients with the acute type of adult T\u2010cell leukemia (ATL). Specific abnormalities in chromosome 14 at break band q11 with the assigned locus of the \u03b1\u2010chain gene of the T\u2010cell antigen receptor were identified in 6 of 8 patients. Inv(l4) (q11q32) was found in 2 patients and translocation of chromosome 14 at break band q 11 was observed in 4. Donor chromosomes involved in translocation of the 14q11 varied, <jats:italic>i.e.<\/jats:italic>, chromosomes 3, 7 or X, with the exception of one patient whose donor chromosome origin could not be determined. The breakpoint in chromosome 3 was in band p25, a region reported to include the locus of the <jats:italic>c\u2010raf<\/jats:italic>\u2010l oncogene. In chromosome 7, it was in band p11, a region reported to include the locus of the c\u2010erb\u2010B oncogene, and in the sex chromosome X, it was in band q11. One patient also had a chromosome 14 aberration at break band q32. Of the 2 remaining patients, one had lost chromosome 14 and the other had an isochro\u2010mosome 14q. Our observation and other reported findings suggest that the rearrangement of chromosome 14 at break band q11 is specific for lymphoma\u2010type or acute\u2010type ATL patients, and aberrations of proto\u2010oncogene expression or the coding sequence by recombination involving a T\u2010cell antigen receptor gene due to chromosome inversion or chromosome translocation may play an important role in T\u2010cell neoplasia including ATL.<\/jats:p>","DOI":"10.1002\/ijc.2910400405","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:06:41Z","timestamp":1171919201000},"page":"461-468","source":"Crossref","is-referenced-by-count":13,"title":["Specific abnormalities of chromosome 14 in patients with acute type of adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Kanji","family":"Miyamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Ishn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoaki","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Yawata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Tada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kitajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0165-4608(79)90020-7","article-title":"Human chronic lymphocytic leukemia: karyo types in different lymphocyte populations","volume":"1","author":"Autio K.","journal-title":"Cancer Genet. 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