{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T19:37:35Z","timestamp":1710963455201},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6819,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1987,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seminomas and control tissues were analyzed for several tumor markers. Very high levels of placental alkaline phosphatase (PLAP)\u2010like enzyme levels were found in all 18 seminomas studied. The majority of the seminomas were of phenotype I, thus differing from placental FLAP. The mean amount of enzyme protein as measured by monoclonal antibodies, was 100 times higher than in non\u2010malignant tissues and 10 times lower than in placental tissue. The specific enzymatic activity in seminomas was about half of that observed in placenta. Similarly, the specific activity of PLAP\u2010like enzymes in sera of patients with seminoma was only about half of that found in pregnancy sera. HCG was strongly elevated in 3 seminomas, but not obviously related to FLAP. Thirteen of the 17 pure seminomas had HCG over 100 IU\/g, which was not seen in normal testes. Liver alkaline phosphatase (LAP) and intestinal alkaline phosphatase (IAP) were high in seminomatous tissues, the mean increases being 60\u2010fold and 20\u2010fold, respectively. The highest IAP levels were found in 2 yolk\u2010sac tumors. Ferritin was moderately elevated in seminomas, but high in several control tissues. Carcinoembryonic antigen (CEA) was not elevated and alpha\u2010fetoprotein (AFP) was not detected at all in pure seminomas. A decrease in carbohydrate antigen 50 (CA\u201050) content was noted in seminomas as compared to normal testes, yolk\u2010sac tumors and choriocarcinomas. Defects in tumor\u2010related enzymes may account for increase of PLAP and decrease of CA\u2010SO.<\/jats:p>","DOI":"10.1002\/ijc.2910400507","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:06:03Z","timestamp":1171919163000},"page":"615-619","source":"Crossref","is-referenced-by-count":6,"title":["Patterns of seminoma tissue markers and deletions"],"prefix":"10.1002","volume":"40","author":[{"given":"H.","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Rud\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ljungdahl\u2010St\u00e5hle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Brehmer\u2010Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hisazumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Stigbrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wahren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861201)58:11<2428::AID-CNCR2820581113>3.0.CO;2-I"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0586-44"},{"key":"e_1_2_1_4_1","first-page":"34","volume-title":"Tumor marker antigens, pp","author":"Hammarstrom S.","year":"1985"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1016\/S0021-9258(18)32588-2","article-title":"Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. 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Hirano K. Stigbrand T. Andersson L. Hisazumi H. andWahren B. Profiles of epitope\u2010Defined markers in sera from males with germ cell tumors.Urol. 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