{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:05:39Z","timestamp":1706807139141},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6819,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1987,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV)\u2010negative Burkitt lymphoma lines (BLE\u2010) and their <jats:italic>in vitro<\/jats:italic> EBV\u2010converted sublines (BLEc), obtained by infection with the P3HR1 and B95\u20108 strains of EBV, were compared for their capacity to induce T\u2010lymphocyte proliferation in allogeneic mixed lymphocyte cultures (MLC). Regardless of the virus strain used for conversion, the BLEc lines induced a considerably stronger primary MLC response than their EBV\u2010negative parentals. Only the BLEc lines were able to maintain T\u2010lymphocyte proliferation in repeated stimulations. The low proliferative response observed in cultures stimulated with BLE<jats:sup>\u2212<\/jats:sup>cells was not due to the generation of suppressor cells or to the release of inhibitory factors. The increased stimulatory capacity of BLEc lines was unrelated to changes in expression of MHC class\u2010I and class\u2010II antigen, or of B\u2010cell activation markers, and was not due to the reactivation of EBV\u2010specific memory T cells, since lymphocytes from EBV\u2010seropositive and seronegative donors responded similarly. The results indicate that the capacity of BL cells to elicit cellular immune responses may be influenced by their EBV\u2010carrying status.<\/jats:p>","DOI":"10.1002\/ijc.2910400521","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:06:03Z","timestamp":1171919163000},"page":"691-697","source":"Crossref","is-referenced-by-count":42,"title":["Paired Epstein\u2010Barr virus (EBV)\u2010negative and EBV\u2010converted Burkitt lymphoma lines: Stimulatory capacity in allogeneic mixed lymphocyte cultures"],"prefix":"10.1002","volume":"40","author":[{"given":"J.","family":"Avila\u2010Cari\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Torsteinsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ehlin\u2010Henriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Masucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.7.4549"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90296-9"},{"key":"e_1_2_1_4_1","first-page":"4562","article-title":"Self stimulating growth factor production by B\u2010Cell lines derived from Burkitt's lymphomas and other lines transformed in vitro by Epstein\u2010Barr virus","volume":"43","author":"Blazar B. A.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1128\/jvi.43.3.952-968.1982","article-title":"Deletion of the non transforming Epstein\u2010Barr virus strain P3HR\u20101 causes fusion of the large internal repeat to the DS1 region","volume":"43","author":"Bornkamm G. W.","year":"1982","journal-title":"J. Virol."},{"key":"e_1_2_1_6_1","first-page":"77","article-title":"Isolation of mononuclear cells and monocytes from human blood. Isolation of mononuclear cells by combining centrifugation and sedimentation","volume":"21","author":"B\u00f6yum A.","year":"1968","journal-title":"Scand. J. clin. Lab. Invest. Suppl."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(85)90220-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4163-5_2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910390215"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310206"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/310145a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.3.231"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4049\/jimmunol.122.2.497","article-title":"Macrophage factor controlling differentiation of B\u2010Cells","volume":"122","author":"Hoffman M. K.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830160720"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.4.1021"},{"key":"e_1_2_1_16_1","first-page":"49","article-title":"Human cytotoxic T lymphocytes. III. Large numbers of peripheral blood T cells clonally develop into allorestricted anti\u2010Viral cytotoxic T cell populations in vitro","volume":"3","author":"Kabelitz D.","year":"1987","journal-title":"Mol. Cell Immunol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90329-X"},{"key":"e_1_2_1_18_1","first-page":"4210","article-title":"T\u2010Cell response to B\u2010Cells and Epstein\u2010Barr virus antigens in infectious mononucleosis","volume":"41","author":"Klein E.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90449-X"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.4049\/jimmunol.130.4.1985","article-title":"Induction of an activated B lymphocyte\u2010Associated surface moiety defined by the B2 monoclonal antibody by EBV conversion of an EBV negative lymphoma line (ramos): differential effect of transforming (b95\u20138) and nontrans\u2010Forming (p3HR\u20101) EBV substrains","volume":"130","author":"Klein G.","year":"1983","journal-title":"J. Immunol."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310503"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90014-4"},{"key":"e_1_2_1_23_1","first-page":"309","volume-title":"Burkitt's lymphoma: a human cancer model","author":"Lenoir G. M.","year":"1985"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820301)49:5<1016::AID-CNCR2820490527>3.0.CO;2-H"},{"key":"e_1_2_1_25_1","first-page":"817","article-title":"Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro","volume":"3","author":"Lundgren G.","year":"1968","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170613"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.13.4567"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(85)90264-3"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.4049\/jimmunol.136.5.1899","article-title":"Functional properties of tumor infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes","volume":"136","author":"Miescher S.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.4049\/jimmunol.130.2.626","article-title":"Levels of mIa expression in mitogen stimulated B lymphocytes is dependent on the position in the cell cycle","volume":"130","author":"Monroe J. G.","year":"1983","journal-title":"J. Immunol"},{"key":"e_1_2_1_31_1","first-page":"315","article-title":"Two monoclonal antibodies raised against a Burkitt lymphoma cell line recognize different cell types within lymphoid follicles","volume":"59","author":"Murray L.","year":"1985","journal-title":"Clin. exp. Immunol."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910110302"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/283583a0"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90329-1"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/jnci\/77.3.681","article-title":"Endemic Burkitt lymphoma: phenotypic analysis of tumor biopsy cells and of derived tumor cell lines","volume":"77","author":"Rooney C. M.","year":"1986","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340310"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/317629a0"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290403"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370307"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04540.x"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350404"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.4049\/jimmunol.131.3.1160","article-title":"Antigen presentation by human monocytes: evidence for stimulant processing and requirement for interleukin I","volume":"131","author":"Scala G.","year":"1983","journal-title":"J. Immunol"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0308-2261(82)80005-2","article-title":"The normal and malignant germinal centre","volume":"11","author":"Stein H.","year":"1982","journal-title":"Clin. Haematol."},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(76)90302-0"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(77)90035-4"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340610"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.15.5620"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90205-2"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6485"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(76)90693-5"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(77)80024-4"},{"key":"e_1_2_1_52_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.4049\/jimmunol.128.2.823","article-title":"B lymphoblast antigen (bB\u20101) expressed on Epstein\u2010Barr virus\u2010Activated B\u2010Cell blasts, B\u2010Lymphoblastoid cell lines and Burkitt's lymphomas","volume":"128","author":"Yokochi T.","year":"1982","journal-title":"J. Immunol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910400521","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910400521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:02:38Z","timestamp":1695801758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910400521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11,15]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,11,15]]}},"alternative-id":["10.1002\/ijc.2910400521"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910400521","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11,15]]}}}