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Careful removal of stromal tissue from the pathological specimens allowed authentic tumor DNA to be processed. Normal genital tissue obtained from the patients and genital condylomata were included as internal controls. The presence of HPV\u201016 or 18 DNA was detected in 12\/13 (92.3%) intraepithelial neoplasms and in 16\/30 (53.3%) invasive carcinomas. No significant difference was detected in titer or frequency of antibodies to HPV group\u2010specific antigen in sera from patients and controls. Hybridization to BgIII N fragment of HSV\u20102 DNA was detected in 4\/13 (30.8%) intraepithelial neoplasms and 4\/30 (13.3%) invasive carcinomas but in none of the control tissues. All the 8 samples harboring HSV\u20102 homologous sequences were also positive for HPV, supporting the hypothesis of a synergistic association between the 2 viruses. The hybridization analyses performed to study c\u2010<jats:italic>myc<\/jats:italic> involvement in genital oncogenesis did not reveal c\u2010<jats:italic>myc<\/jats:italic> amplification in either invasive or pre\u2010invasive lesions.<\/jats:p>","DOI":"10.1002\/ijc.2910400609","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:05:39Z","timestamp":1171919139000},"page":"763-768","source":"Crossref","is-referenced-by-count":31,"title":["Simultaneous presence of herpes simplex and human papilloma virus sequences in human genital tumors"],"prefix":"10.1002","volume":"40","author":[{"given":"D.","family":"Di Luca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rorola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pilotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Monini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Caselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rilke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Cassai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350105"},{"key":"e_1_2_1_3_1","first-page":"62","volume-title":"Herpes and papilloma viruses","author":"Aurelian L.","year":"1986"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90006-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01944.x"},{"key":"e_1_2_1_6_1","first-page":"596","volume-title":"Sexually transmitted diseases","author":"Briggs R. 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