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We now report further investigations on the role of PKC using 2 selective enzymatic inhibitors [l\u2010(5\u2010lsoquinolinylsulfonyl)\u20102\u2010meth\u2010ylpiperazine] (H\u20107) and Staurosporine. We show that these inhibitors can abrogate the inductive effect of TPA or the combination of TPA plus n\u2010butyrate. The inhibitors have no effisct on induction by calcium ionophores or by viral super\u2010infection. In this context the effect of verapamil (a specific calcium channel blocker) and of several calmodulin antagonists was investigated. No inhibitory effect of these agents could be demonstrated on any of the induction systems examined. These observations strengthen the idea that in some instances cellular PKC plays a role in the expression of viral antigens; however, alternative regulatory mechanisms cannot be excluded.<\/jats:p>","DOI":"10.1002\/ijc.2910400624","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:05:39Z","timestamp":1171919139000},"page":"846-849","source":"Crossref","is-referenced-by-count":17,"title":["TPA induction of Epstein\u2010Barr virus early antigens in Raji cells is blocked by selective protein kinase\u2010C inhibitors"],"prefix":"10.1002","volume":"40","author":[{"given":"Janis","family":"Lazdins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Zompetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Settimio","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Barile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Venanzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Frati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Faggioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"141","article-title":"Vasodilatory action of HA1004 [n\u2010(2\u2010Guanidinoethyl)\u20105\u2010Isoquinolinesulfonamide], a novel calcium antagonist with no effect on cardiac function","volume":"231","author":"Asano T.","year":"1984","journal-title":"J. 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