{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:51:04Z","timestamp":1760975464971},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6759,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies were made to determine whether freshly isolated monocytes from healthy donors could influence the induction of lymphokine (IL\u20102)\u2010activated killer (LAK) activity. Highly purified lymphocytes ( &gt; 99%) and monocytes (&gt;90%) were isolated by counter\u2010flaw centrifugal elutriation from peripheral blood. Lymphocytes incubated for 4 days with IL\u20102 showed significant LAK activity against natural killer (NK) cell\u2010resistant target (Daudi) cells, whereas monocytes treated for 4 days with IL\u20102 and\/or IFN\u2010\u03b3 were not cytotoxic. Under the experimental conditions used, addition of monocytes to the lymphocyte cultures resulted in significant augmentation of the LAK activity, depending on the density of monocytes added. In contrast, monocytes stimulated by lipopolysaccha\u2010ride (LPS) markedly suppressed LAK activity induced by IL\u20102, depending on the dose of LPS added. Similar up\u2010 and down\u2010regulations of LAK cell induction by monocytes were observed with 4 lines of human lung cancer cells as targets for LAK activity. Although supernatants from untreated monocytes did not increase LAK induction, supernatants from LPS\u2010stimulated monocytes suppressed LAK induction. The regulatory role of monocytes could not be replaced by the addition of exogenous interleukin I (IL\u20101) or tumor necrosis factor (TNF). Prostaglandin E did not seem to play a regulatory role, since addition of indomethacin did not affect the regulation of LAK cell induction by monocytes\u2010 These results clearly indicate that human monocytes may cause up\u2010 or down\u2010regulation of the expression of IL\u20102 induced LAK activity, depending on their functional state.<\/jats:p>","DOI":"10.1002\/ijc.2910410108","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:01:11Z","timestamp":1171918871000},"page":"33-40","source":"Crossref","is-referenced-by-count":38,"title":["Up\u2010 and down\u2010regulation of human lymphokine (IL\u20102)\u2010activated killer cell induction by monocytes, depending on their functional state"],"prefix":"10.1002","volume":"41","author":[{"given":"Akihiko","family":"Nil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saburo","family":"Sone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiro","family":"Utsugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yanagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(85)90028-0"},{"key":"e_1_2_1_3_1","first-page":"419","article-title":"Changes in the macrophage content of lung metastases at different stages in tumor growth","volume":"118","author":"Bugelski P. 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