{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:44Z","timestamp":1764688604976},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6758,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A quantitative <jats:italic>in vivo<\/jats:italic> assay for evaluating the tumorigenicity of Burkitt's lymphoma (BL) cell lines in nude mice is described. It is based on the dose\u2010response kinetics of BL cell tines in pre\u2010irradiated (480 rad) nude mice following the s.c. injection of 4 different cell doses. This model system was used to estimate the xenografting potential of 26 BL cell lines derived from BL patients of different geographic and ethnic origins, as well as lymphoblastoid cell lines (LCLs) established by Epstein\u2010Barr virus (EBV) immortalization of normal B lymphocytes. The results indicate that most BL cell lines are tumorigenic, but LCLs fail to produce progressively growing tumours in nude mice. However, BL cell lines revealed individual degrees of tumorigenicity and accordingly could be divided into 4 groups with high, moderate, low or no tumorigenicity. Preliminary attempts to correlate the xenografting phenotype of BL lines with other characteristics indicate that: (1) the aberrations of chromosome I are more often encountered in cell lines with high and moderate tumorigenicity; (2) EBV\u2010positive BL lines do nat reveal a higher tumorigenic phenotype in comparison with EBV negative ones; (3) cell lines carrying translocations t(8;22) and t(2;B) might fall more frequently in the group of lines with high and moderate tumorigenicity; and (4) when LCLs grow in nu\/nu mice, rejection always occurs and is associated with massive tumour necrosis. These findings suggest that the tumorigenicity of BL cell lines in immunosuppressed animals is nat related with EBV, but with certain chromosomal abnormalities (BL\u2010specific and nonspecific) indicating that this <jats:italic>in vivo<\/jats:italic> model system can be instrumental for the identification of other factors or stages involved in BL development.<\/jats:p>","DOI":"10.1002\/ijc.2910410117","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:01:11Z","timestamp":1171918871000},"page":"87-95","source":"Crossref","is-referenced-by-count":38,"title":["Burkitt's lymphoma cell lines reveal different degrees of tumorigenicity in nude mice"],"prefix":"10.1002","volume":"41","author":[{"given":"V. E.","family":"Gurtsevitch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"O'Conor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90071-1"},{"key":"e_1_2_1_3_1","first-page":"143","article-title":"Existe\u2010t\u2010il une \u00e9quivalence fonctionnelle entre anomalies du bras long du chromosome du virus d'Epstein\u2010Barr dans les lign\u00e9es continues de lympbome de Burkitt?","volume":"298","author":"Berger R.","year":"1984","journal-title":"C.R. Acad. Sci. Paris"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90138-3"},{"key":"e_1_2_1_5_1","unstructured":"Buzuki S. Mikata R. Suzuki H. Kageyama K. Tsutsumi Y. Tamura S. andKinoshita Y. Xenotransplantation of lymphoblastoid cell lines.Proc. of 39th Annual Meeting of the Japanese Cancer Association Yokyo(1980)."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340405"},{"key":"e_1_2_1_7_1","series-title":"IARC Scientific Publications 51","first-page":"113","volume-title":"Modulators of experimental carcinogenesis","author":"Deichman G. I.","year":"1983"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/274756a0"},{"key":"e_1_2_1_9_1","first-page":"289","article-title":"Lymphoid cell lines: In vitro cell markers in correlation to tumorigenicity in nude mice","volume":"20","author":"Diehl U.","year":"1977","journal-title":"Haematol. Bluttransfus."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.4.781"},{"key":"e_1_2_1_11_1","first-page":"51","article-title":"Chromosome I abnormalities: a common feature of pediatric solid rumors","volume":"75","author":"Douglass E. C.","year":"1985","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)91524-7"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310206"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910240118"},{"key":"e_1_2_1_15_1","first-page":"201","volume-title":"Advances in Viral Oncology","author":"Henle W.","year":"1985"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1985.45"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910060102"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320467"},{"key":"e_1_2_1_19_1","first-page":"88","article-title":"Multiple growth parameters of lymphoid cell lines transplanted into nude mice","volume":"9","author":"Kirchner H. H.","year":"1981","journal-title":"Exp. Hematol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/315190a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304085"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69860-6_2"},{"key":"e_1_2_1_23_1","first-page":"283","volume-title":"Pathogenesis of leukemias and lymphomas: environmental influences","author":"Lenoir G. M.","year":"1984"},{"key":"e_1_2_1_24_1","unstructured":"Lenoir G. M. andTaub R. Chromosomal translocations and oncogenes in Burkitt's lymphoma.In: J\u2010M. Goldman and D.G. Harnden (eds.) Genetic rearrangements in leukemia and lymphoma Vol. 2 pp.152\u2013171 Edinburgh (1986)."},{"key":"e_1_2_1_25_1","series-title":"IARC Scientific Publications 60","first-page":"309","volume-title":"Burkitt's lymphoma, a human cancer model","author":"Lenoir G. 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