{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:28:21Z","timestamp":1791080901398,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6668,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To clarify the intrinsic factors involved in the manifestation of adult T\u2010cell leukemia\/lymphoma (ATL) in Japan, a third nation\u2010wide study on ATL was conducted by the T\u2010 and B\u2010cell Malignancy Study Group. General clinico\u2010epidemiological findings on ATL and infectious modes of transmission of human T\u2010lymp ho tropic virus type I (HTLV\u2010I) from 181 ATL patients and their relatives were analyzed and the frequency of HLA antigens in 64 ATL patients was compared with that of 48 relatives of ATL pro bands, 340 controls from all Japan and 236 controls from Kyushu (Tanaka <jats:italic>et al.<\/jats:italic>, 1984). General findings on ATL were mostly the same as those in the 2 previous nation\u2010wide studies. The age\u2010specific positivity rate of anti\u2010HTLV\u2010I antibody in siblings of ATL patients was markedly higher than that in children of ATL patients. This suggests that there is a high risk of mothers of ATL patients transmitting HTLV\u2010I to their children who may develop clinical ATL after reaching ATL risk age. Frequencies of HLA antigens A26 and B39, among patients with ATL in ATL\u2010endemic areas (Kyushu and South Shikoku), were higher (RR&gt;2.0 and p&lt;0.05) than those of controls in Kyushu, and lower (RR&lt;0.5 and p &lt; 0.05) with respect to A24, Bw46, BwSI, Bw61 and DR7. The frequency of BwS2 was also lower in relatives positive for anti\u2010HTLV\u20101 antibody than in relatives without antibody. However, these differences were not statistically significant after correction for the 45 antigens typed. These results can neither support nor refute the possibility of genetic susceptibility to HTLV\u20101 infection and manifestation of ATL.<\/jats:p>","DOI":"10.1002\/ijc.2910410406","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:00:35Z","timestamp":1171918835000},"page":"505-512","source":"Crossref","is-referenced-by-count":54,"title":["The third nation\u2010wide study on adult T\u2010cell leukemia\/lymphoma (ATL) in Japan: Characteristic patterns of hla antigen and HTLV\u2010I infection in atl patients and their relatives"],"prefix":"10.1002","volume":"41","author":[{"name":"The T\u2010 and B\u2010cell Malignancy Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290606"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_4_1","first-page":"845","article-title":"A new agglutination test for serum antibodies to adult T\u2010cell leukemia virus","volume":"75","author":"Ikeda M.","year":"1984","journal-title":"Gann."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1182\/blood.V66.1.120.120","article-title":"Preleukemic state of adult T\u2010cell leukemia abnormal T lymphocytosis, induced by human adult T\u2010cell leukemia\u2010lymphoma virus","volume":"66","author":"Kinoshita K.","year":"1985","journal-title":"Blood."},{"key":"e_1_2_1_6_1","first-page":"103","article-title":"Demonstration of adult T\u2010cell leukemia virus antigen in milk from three sero\u2010positive mothers","volume":"75","author":"Kinoshita K.","year":"1984","journal-title":"Gann."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350609"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330602"},{"key":"e_1_2_1_9_1","first-page":"485","article-title":"Characteristics of a leukeniic T\u2010cell line derived from adull T\u2010cell leukemia","volume":"9","author":"Miyoshi I.","year":"1979","journal-title":"Jap. J. clin. Oncul."},{"key":"e_1_2_1_10_1","first-page":"1014","article-title":"Search for possible routes of vertical and horizontal transmission of adult T\u2010cell leukemia virus","volume":"75","author":"Nakano S.","year":"1984","journal-title":"Gann."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_12_1","first-page":"314S","article-title":"Association between an HLA haplotype and low responsiveness to schistosomal worm antigen in man","volume":"152","author":"Sasazuki T.","year":"1980","journal-title":"J. exp. Med."},{"key":"e_1_2_1_13_1","first-page":"357","article-title":"A comparison of clinical, morphologic and immunologic characteristics of adult T\u2010cell leukemia\u2010lymphoma and cutaneous T\u2010cell lymphoma","volume":"9","author":"Shimoyama M.","year":"1979","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_14_1","first-page":"245","article-title":"Anti\u2010ATLA (antibody to adult T\u2010cell leukemia\u2010lymphoma virus\u2010associated antigen)\u2010negative adult T\u2010cell leukemia\u2010lymphoma","volume":"13","author":"Shimoyama M.","year":"1983","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_15_1","first-page":"347","article-title":"HLA antigens and aduh T\u2010cell leukemia virus infection: a community based study in the Goto Islands. Japan","volume":"14","author":"Tajima K.","year":"1984","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_16_1","first-page":"423","article-title":"Estimation of rale of incidence of ATL among ATLV (HTLV\u2010I) carriers in Kyushu, Japan","volume":"15","author":"Tajima K.","year":"1985","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910370309"},{"key":"e_1_2_1_18_1","first-page":"893","article-title":"Epidemiological analysis of the distribution of antibody to adult T\u2010cell leukemia\u2010virus\u2010associated antigen (ATLA): possible horizontal transmission of adult T\u2010cell leukemia virus","volume":"73","author":"Tajima K.","year":"1982","journal-title":"Gann."},{"key":"e_1_2_1_19_1","first-page":"495","article-title":"Geographical features and epidemiological approach to endemic T\u2010cell Ieukemia\/lymphoma in Japan","volume":"9","author":"Tajima K.","year":"1979","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1984.tb00013.x"},{"key":"e_1_2_1_21_1","first-page":"15","article-title":"The T\u2010 and B\u2010cell. Malignancy Study Group, Statistical analysis of immunologiC., clinical and histopathologic data on lymphoid malignancies in Japan","volume":"11","year":"1981","journal-title":"Jap. J. clin. Oncol."},{"key":"e_1_2_1_22_1","first-page":"517","article-title":"The T\u2010 and B\u2010Cell Malignancy Study Group, Statistical analyses of clinico\u2010pathological, virological and epidemiological data on lymphoid malignancies with special references to adult T\u2010tell leukemia\/lymphoma: a report of the second nationwide study of Japan Jap","volume":"15","year":"1935","journal-title":"J. clin Onlot."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1182\/blood.V62.4.758.758","article-title":"A proposal for smoldering adult T\u2010cell leukemia: a clinicopathologic study of five eases","volume":"62","author":"Yamaguchi K.","year":"1983","journal-title":"Blood."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910410406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910410406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T04:30:35Z","timestamp":1697949035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910410406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4,15]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,4,15]]}},"alternative-id":["10.1002\/ijc.2910410406"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910410406","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4,15]]}}}