{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T08:55:51Z","timestamp":1754556951059},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6638,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monoclonal antibody (MAb) 12\u20104LE reacts specifically with the \u03b1Fuc(1\u20102)\u03b2Gal(1\u20104)[\u03b1Fuc(1\u20103)]GlcNAc\u2010R synthetic oligosaccharide and consequently characterizes the Y (Le<jats:sup>y<\/jats:sup>) antigen. In normal individuals, this MAb reacts more strongly on samples from blood group O persons, indicating that the Y structure is better recognized when terminal A or B sugars are not added to the Y structure. In fetal and normal adult gastrointestinal tract, this antibody reacts with the epithelium of stomach, small intestine and proximal colon, but not of distal colon. In the adult, cells from the surface epithelium of the gastric, small intestinal and cecal mucosae express the Y antigen according to the secretor phenotype of each individual, thus characterizing the so\u2010called \u201cupward differentiation\u201d pattern. In contrast, mucus cells of the pylorus and duodenal Br\u00fcnner glands, as well as Paneth cells, always express the Y antigen irrespective of secretor phenotype, thereby characterizing the so\u2010called \u201cdownward differentiation\u201d pattern. Proximal fetal colonic mucosa has the same genetic control as the downward differentiation pattern of the adult. Distal fetal colonic mucosa is negative with anti\u2010Y, as in the adult. Y antigen was not expressed in hyperplastic (10 cases), juvenile (5 cases) or adenomatous (42 cases) polyps, except for some spreading villous adenomas in which rare Y\u2010positive foci could be observed but which were not specifically associated with dysplastic glands. Polyps from familiar polyposis did not express this antigen. In adenocarcinomas, the Y antigen was expressed in 41\/45 (91%) of distal tumors and 15\/35 (43%) of cecal tumors, independently of ABO phenotype. The ectopic expression of this Y antigen on distal colon adenocarcinomas may be a useful tool in the detection of distal colonic carcinomas.<\/jats:p>","DOI":"10.1002\/ijc.2910410508","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:20:20Z","timestamp":1171920020000},"page":"683-689","source":"Crossref","is-referenced-by-count":17,"title":["Ectopic expression of the Y (Le<sup>y<\/sup>) antigen defined by monoclonal antibody 12\u20104LE in distal colonic adenocarcinomas"],"prefix":"10.1002","volume":"41","author":[{"given":"Jacques","family":"Bara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosella","family":"Mollicone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenie","family":"Herrero\u2010Zabaleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolphe","family":"Gautier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagib","family":"Daher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Oriol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2639","article-title":"Differential expression of difucosyl type 2 chain (Ley) defined by monoclonal antibody AH6 in different locations of colonic epithelia, various histological types of colonic polyps and adenocarcinomas","volume":"46","author":"Abe K.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(80)90286-8"},{"key":"e_1_2_1_4_1","first-page":"3983","article-title":"Monoclonal antibodies against oncofetal mucin M1 antigens associated with precancerous colonic mucosae","volume":"46","author":"Bara J.","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/85.2.152"},{"key":"e_1_2_1_6_1","first-page":"3885","article-title":"Immunohistological study of precancerous mucus modification in human distal colonic polyps","volume":"43","author":"Bara J.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.77"},{"key":"e_1_2_1_8_1","first-page":"23","article-title":"Immunologic study of blood group substances in rectocolon diseases","volume":"2","author":"Blasco E.","year":"1987","journal-title":"J. clin. 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