{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:46:31Z","timestamp":1758278791697},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":6606,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DU\u2010PAN\u20102 is a high\u2010molecular\u2010weight glycoprotein defined by a murine monoclonal antibody (MAb) elicited against a human pancreatic adenocarcinoma cell line. This MAb recogonizes an oncofetal antigen present on the surface of normal pancreatic and bile\u2010duct epithelium, normal bronchus epithelium, and some adenocarcinomas. Elevated levels of the antigen (&gt; 400 U\/ml) have been detected in the serum of 79% of patients with adenocarcinoma of the pancreas and in a small percentage of patients with other adenocarcinomas, by means of a competition radioimmunoassay. Here, we have studied DU\u2010PAN\u20102 antigen levels in sera of patients with a spectrum of hepatobiliary diseases and controls. Serum DU\u2010PAN\u20102 antigen was elevated in 59% of 112 patients with non\u2010malignant hepatobiliary diseases and in 50% of hepatoma patients. None of 50 healthy controls had elevated serum DU\u2010PAN\u20102 levels. Patients in every category of hepatobiliary disease studied had elevated median serum DU\u2010PAN\u20102 levels; the highest median levels were seen in patients with primary biliary cirrhosis (1,296 U\/ml) and the lowest in stable cirrhosis (300 U\/ml). Elevated serum DU\u2010PAN\u20102 levels in one patient with primary biliary cirrhosis and in one patient with hepatoma returned to normal following liver transplantation. Serum DU\u2010PAN\u20102 levels did not correlate well with alkaline phosphatase, 5\u2032\u2010nucleotidase, bilirubin, or \u03b1\u2010fetoprotein. Using an immunoperoxidase technique on formalin\u2010fixed, deparaffinized liver sections, we showed that DU\u2010PAN\u20102 MAb reacted heterogeneously with bile\u2010duct epithelium but never stained hepatocytes or hepatoma cells. While serum DU\u2010PAN\u20102 levels may be useful in detecting and monitoring pancreatic adenocarcinoma, they are not specific for this disease.<\/jats:p>","DOI":"10.1002\/ijc.2910410602","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T11:48:28Z","timestamp":1224244108000},"page":"789-793","source":"Crossref","is-referenced-by-count":11,"title":["Detection of an oncofetal antigen (DU\u2010PAN\u20102) in sera of patients with non\u2010malignant hepatobiliary diseases and hepatomas"],"prefix":"10.1002","volume":"41","author":[{"given":"Ann E.","family":"Haviland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Borowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"Killenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Metzgar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/ajcp\/79.3.387","article-title":"Lymphoblastic lymphoma with the phenotype of common acute lymphoblastic leukemia","volume":"79","author":"Borowitz M. J.","year":"1983","journal-title":"Amer. J. clin. Path."},{"key":"e_1_2_1_3_1","first-page":"999","article-title":"Monoclonal antibodies against human pancreatic adenocarcinoma: distribution of DU\u2010PAN\u20102 antigen on glandular epithelia and adenocarcinomas","volume":"72","author":"Borowitz M. J.","year":"1984","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_4_1","first-page":"519","article-title":"Distribution of alkaline phosphatase activity in healthy and diseased human liver tissue","volume":"83","author":"Hagerstrand I.","year":"1975","journal-title":"Acta path. microbiol, scand."},{"key":"e_1_2_1_5_1","first-page":"305","article-title":"Isolation and properties of a human panereatic adenocarcinoma\u2010associated antigen, DU\u2010PAN\u20102","volume":"45","author":"Lan M. S.","year":"1985","journal-title":"Cancer Res."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198510000-00005"},{"key":"e_1_2_1_7_1","first-page":"169","volume-title":"Monoclonal antibodies in in vitro diagnosis of tumors","author":"Metzgar R. S.","year":"1988"},{"key":"e_1_2_1_8_1","first-page":"601","article-title":"Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies","volume":"42","author":"Metzgar R. S.","year":"1982","journal-title":"Cancer Res."},{"key":"e_1_2_1_9_1","first-page":"63","volume-title":"Monoclonal antibodies and cancer therapy","author":"Metzgar R. 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