{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:23:03Z","timestamp":1698362583224},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6546,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1988,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distribution of a novel human angiogenic factor (HAF) (Schulze Ostoff et al., 1987) has been investlgated on various human cell lines, isolated blood cells as well as in normal, inflammatory and tumor tissues. Localization was performed by using the monoclonal antibody (MAb) 5F4 directed against HAF. It was found that 30% of freshly isolated human monocytes expressed the 5F4 antigen. The number of postitive cells increased to 75\u201390% on day 4 to 7 upon culture and then decreased. Twenty percent of freshly isolated human lymphocytes also stained positively, whereras graunlocytes and platelets were negative. In cryostat sections of normal human tissue (skin, lung, liver, spleen, placenta) 5F4 is positive with capillary endothelial cells and few macrophages. In inflammatory tissue derived from gingivitis and rheumatoid arthrritis, more macrophages than in normal tissues and less endothelial cell were postitive, In tumor tissues some endothelia cells and a subset of tumor\u2010infiltrating macrophages expressed the antigen. Tumor cells were positive in advanced melanoms, but only occasionlally in stomach carcinomas. We conclude that the angiogenic factor is produced mainly by a subset of inflammatory macrophages which appear to be the principal source of HAF in regenerating or growing tissues.<\/jats:p>","DOI":"10.1002\/ijc.2910420211","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:17:42Z","timestamp":1171919862000},"page":"207-212","source":"Crossref","is-referenced-by-count":8,"title":["Immunolocalization of an angiogenic factor (HAF) in normal, inflammatory and tumor tissues"],"prefix":"10.1002","volume":"42","author":[{"given":"B\u00e4rbel","family":"Fr\u00f6hbeis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Zwadlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva\u2010Bettina","family":"Bro\u00f6cker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Schulze","family":"Osthoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana\u2010Hermann","family":"Hagemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Topoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemenns","family":"Sorg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"3435","article-title":"Angiogenesis induction by tumors, embryonic tissues, and lymphocytes","volume":"36","author":"Auerrbach R.","year":"1976","journal-title":"Cancer Res."},{"issue":"97","key":"e_1_2_1_3_1","first-page":"77","article-title":"Isolation of monouclear cells and granulocytes form human blood","volume":"21","author":"Boyum A.","year":"1968","journal-title":"Scand. J. clin. Lab. Invest."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00199208"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(82)90315-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(84)90258-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00341a030"},{"key":"e_1_2_1_9_1","first-page":"2109","article-title":"Tumor angiogenesis factor","volume":"34","author":"Folkaman J.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(87)90370-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432664"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.15.5277"},{"key":"e_1_2_1_13_1","first-page":"537","article-title":"An evaluation of the role of leukocytes in the pathogesis of experimentally induced corneal vascularization","volume":"79","author":"Fromer C. H.","year":"1975","journal-title":"Amer. J. Path."},{"key":"e_1_2_1_14_1","first-page":"117","article-title":"Characterazition and expression kinetics of an endothelial cell activation antiogen present in vivo only in actue inflammatory tissues","volume":"55","author":"Goerdt S.","year":"1987","journal-title":"Exp. Cell Biol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.2.847"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/329630a0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(86)90487-2"},{"key":"e_1_2_1_18_1","first-page":"171","article-title":"Absence and presence of fluid form normal and inflamed gingiva","volume":"3","author":"L\u00f6e H.","year":"1965","journal-title":"Preiodontics"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.5.1706"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830101107"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.4049\/jimmunol.136.5.1680","article-title":"Two distinct monokines, interleukin I and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells","volume":"136","author":"Pober J. S.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/269804a0"},{"key":"e_1_2_1_24_1","first-page":"1579","article-title":"Characterization of a chemo\u2010Attractant for endothelium induced by angiogenesis effectors","volume":"44","author":"Raju K. S.","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4167"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2422759"},{"key":"e_1_2_1_27_1","first-page":"3","article-title":"Purification and characterization of a novel human angiogenic factor (h\u2010AF)","volume":"146","author":"Schulze Osthoff K.","year":"1987","journal-title":"Biochem. biophys. Res. Comm."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(86)90322-6"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(83)90181-5"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.4049\/jimmunol.136.10.3773","article-title":"Human T lymphocytes and monocytes bear the same Leu\u20103 (t4) antigen","volume":"136","author":"Stweart S. J.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_32_1","first-page":"467","article-title":"Analysis of inflammatory infiltretes with the aid of monoclonal antibodies in various stages of inflammation of the gingival margin","volume":"42","author":"Topoll H. \u2010H.","year":"1987","journal-title":"Dtsch. Zahn\u00e4rztl. Z."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.131.1.212"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.4049\/jimmunol.134.3.1487","article-title":"A monoclonal antibody and absent form monocytes","volume":"134","author":"Zwadlo G.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4049\/jimmunol.137.2.512","article-title":"A monoclonoal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues","volume":"137","author":"Zwadlo G.","year":"1986","journal-title":"J. Immunol."},{"key":"e_1_2_1_36_1","first-page":"295","article-title":"A monoclonal antibody to a novel differentiation antigen on human macrophages","volume":"55","author":"Zwadlo G.","year":"1988","journal-title":"Exp. Cell Biol."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910420211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910420211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:53:22Z","timestamp":1697856802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910420211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8,15]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,8,15]]}},"alternative-id":["10.1002\/ijc.2910420211"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910420211","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,8,15]]}}}